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Achieving clinically viable 12-cm readout distance from micromachined implantable intraocular pressure sensor using a standard clinical slit lamp

Lee, Jeong Oen and Park, Haeri and Chen, Oliver and Balakrishna, Ashwin and Du, Juan and Sretavan, David W. and Choo, Hyuck (2016) Achieving clinically viable 12-cm readout distance from micromachined implantable intraocular pressure sensor using a standard clinical slit lamp. In: 29th International Conference on Micro Electro Mechanical Systems (MEMS), 2016. IEEE , Piscataway, NJ, pp. 210-213. ISBN 978-1-5090-1973-1. http://resolver.caltech.edu/CaltechAUTHORS:20161013-105118715

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Abstract

Achieving a practical readout distance for implantable intraocular pressure (IOP) sensors is an essential step toward commercialization yet has remained as a major challenge. Using the Zeiss SL-30 slit lamp ??? a standard ophthalmic scope widely used by clinicians, we have demonstrated an optical readout distance of 12 cm from a micromachined IOP sensor implanted in an ex-vivo rabbit eye. We show that we have achieved this readout distance by (1) redesigning the sensing area of the IOP sensor and its fabrication steps to significantly improve the signal-to-noise ratio; and (2) incorporating a novel robust detection algorithm, which includes a much-improved opto-mechanical model, that allows us to remove the background noise and instantaneously map the sensor's optical signal to the corresponding IOP value. A significant increase in readout distance accomplished using a well established ophthalmic clinical scope makes our IOP system a more clinically viable choice.


Item Type:Book Section
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1109/MEMSYS.2016.7421596DOIArticle
http://ieeexplore.ieee.org/xpls/icp.jsp?arnumber=7421596PublisherArticle
ORCID:
AuthorORCID
Choo, Hyuck0000-0002-8903-7939
Additional Information:© 2016 IEEE. Date Added to IEEE Xplore: 29 February 2016. The project has been funded by the Caltech Cl2 program, Powell Foundation, Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (2013R1A6A3A03026384) and BWF.
Funders:
Funding AgencyGrant Number
Caltech Innovation Initiative (CI2)UNSPECIFIED
National Research Foundation of Korea2013R1A6A3A03026384
Ministry of Education (Korea)UNSPECIFIED
Burroughs Wellcome FundUNSPECIFIED
Charles Lee Powell FoundationUNSPECIFIED
Subject Keywords:Biomedical optical imaging, Cavity resonators, Optical device fabrication, Optical reflection, Optical sensors, Rabbits
Record Number:CaltechAUTHORS:20161013-105118715
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:20161013-105118715
Official Citation:J. O. Lee et al., "Achieving clinically viable 12-CM readout distance from micromachined implantable intraocular pressure sensor using a standard clinical slit lamp," 2016 IEEE 29th International Conference on Micro Electro Mechanical Systems (MEMS), Shanghai, 2016, pp. 210-213. doi: 10.1109/MEMSYS.2016.7421596
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:71048
Collection:CaltechAUTHORS
Deposited By: Ruth Sustaita
Deposited On:13 Oct 2016 18:46
Last Modified:13 Oct 2016 18:46

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