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Lanthanum fluoride nanoparticles for radiosensitization of tumors

Kudinov, Konstantin and Bekah, Devesh and Cooper, Daniel and Shastry, Sathvik and Hill, Colin and Bradforth, Stephen and Nadeau, Jay (2016) Lanthanum fluoride nanoparticles for radiosensitization of tumors. In: Colloidal Nanoparticles for Biomedical Applications XI. Proceedings of SPIE. No.9722. Society of Photo-Optical Instrumentation Engineers (SPIE) , Bellingham, WA, Art. No. 97220V. ISBN 9781628419566. https://resolver.caltech.edu/CaltechAUTHORS:20161014-101532110

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Abstract

Dense inorganic nanoparticles have recently been identified as promising radiosensitizers. In addition to dose enhancement through increased attenuation of ionizing radiation relative to biological tissue, scintillating nanoparticles can transfer energy to coupled photosensitizers to amplify production of reactive oxygen species, as well as provide UVvisible emission for optical imaging. Lanthanum fluoride is a transparent material that is easily prepared as nanocrystals, and which can provide radioluminescence at a number of wavelengths through simple substitution of lanthanum ions with other luminescent lanthanides. We have prepared lanthanum fluoride nanoparticles doped with cerium, terbium, or both, that have good spectral overlap with chlorine6 or Rose Bengal photosensitizer molecules. We have also developed a strategy for stable conjugation of the photosensitizers to the nanoparticle surface, allowing for high energy transfer efficiencies on a per molecule basis. Additionally, we have succeeded in making our conjugates colloidally stable under physiological conditions. Here we present our latest results, using nanoparticles and nanoparticle-photosensitizer conjugates to demonstrate radiation dose enhancement in B16 melanoma cells. The effects of nanoparticle treatment prior to 250 kVp x-ray irradiation were investigated through clonogenic survival assays and cell cycle analysis. Using a custom apparatus, we have also observed scintillation of the nanoparticles and conjugates under the same conditions that the cell samples are irradiated.


Item Type:Book Section
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1117/12.2213374DOIArticle
http://proceedings.spiedigitallibrary.org/proceeding.aspx?articleid=2501970PublisherArticle
ORCID:
AuthorORCID
Nadeau, Jay0000-0001-5258-0076
Additional Information:© 2016 Society of Photo-Optical Instrumentation Engineers (SPIE).
Subject Keywords:Photodynamic therapy, radiation therapy, scintillation, radioluminescence, fluorescence lifetimes, energy transfer
Series Name:Proceedings of SPIE
Issue or Number:9722
Record Number:CaltechAUTHORS:20161014-101532110
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20161014-101532110
Official Citation:Konstantin Kudinov ; Devesh Bekah ; Daniel Cooper ; Sathvik Shastry ; Colin Hill ; Stephen Bradforth and Jay Nadeau " Lanthanum fluoride nanoparticles for radiosensitization of tumors ", Proc. SPIE 9722, Colloidal Nanoparticles for Biomedical Applications XI, 97220V (April 22, 2016); doi:10.1117/12.2213374; http://dx.doi.org/10.1117/12.2213374
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:71101
Collection:CaltechAUTHORS
Deposited By: George Porter
Deposited On:14 Oct 2016 18:31
Last Modified:03 Oct 2019 16:04

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