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Low-Temperature Spectroscopy of Biological Compounds

Scott, Jesse F. and Sinsheimer, Robert L. and Loofbourow, John R. (1948) Low-Temperature Spectroscopy of Biological Compounds. Science, 107 (2777). p. 302. ISSN 0036-8075. doi:10.1126/science.107.2777.302.

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It is well substantiated that the absorption spectra of complex molecules may be sharpened, and in many cases the vibrational and rotational details brought out, by refrigeration of the absorbing material to the temperature of liquid nitrogen or lower. This principle seems of great potential utility for the characterization and differentiation of compounds of biological interest heretofore indistinguishable by their absorption characteristics, and conceivably for the solution of cytochemical problems. However, the techniques that have been employed have only limited application to polar compounds. We have therefore developed new techniques with which we have undertaken a study of the absorption spectra of a number of purines, pyrimidines, amino acids, proteins, etc. at the temperature of liquid nitrogen (77° K).

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Additional Information:© 1948 American Association for the Advancement of Science. This work was aided by a grant from the American Cancer Society recommended by the National Research Council Committee on Growth.
Funding AgencyGrant Number
American Cancer SocietyUNSPECIFIED
Donner FoundationUNSPECIFIED
Issue or Number:2777
Record Number:CaltechAUTHORS:20161017-154732901
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Official Citation: Low-Temperature Spectroscopy of Biological Compounds By JESSE F. SCOTT, ROBERT L. SINSHEIMER, JOHN R. LOOFBOUROW Science 19 Mar 1948 : 302
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:71194
Deposited By: George Porter
Deposited On:18 Oct 2016 14:47
Last Modified:11 Nov 2021 04:41

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