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NMR Hyperpolarization Techniques of Gases

Barskiy, Danila A. and Coffey, Aaron M and Nikolaou, Panayiotis and Mikhaylov, Dmitry M. and Goodson, Boyd M. and Branca, Rosa T. and Lu, George J. and Shapiro, Mikhail G. and Telkki, Ville-Veikko and Zhivonitko, Vladimir V. and Koptyug, Igor V. and Salnikov, Oleg G. and Kovtunov, Kirill V. and Bukhtiyarov, Valerii I. and Rosen, Matthew S. and Barlow, Michael J. and Safavi, Shahideh and Hall, Ian P. and Schröder, Leif and Chekmenev, Eduard Y. (2017) NMR Hyperpolarization Techniques of Gases. Chemistry: a European Journal, 23 (4). pp. 725-751. ISSN 0947-6539. PMCID PMC5462469. doi:10.1002/chem.201603884.

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Nuclear spin polarization can be significantly increased through the process of hyperpolarization, leading to an increase in the sensitivity of nuclear magnetic resonance (NMR) experiments by 4-8 orders of magnitude. Hyperpolarized gases, unlike liquids and solids, can be more readily separated and purified from the compounds used to mediate the hyperpolarization processes. These pure hyperpolarized gases enabled many novel MRI applications including the visualization of void spaces, imaging of lung function, and remote detection. Additionally, hyperpolarized gases can be dissolved in liquids and can be used as sensitive molecular probes and reporters. This mini-review covers the fundamentals of the preparation of hyperpolarized gases and focuses on selected applications of interest to biomedicine and materials science.

Item Type:Article
Related URLs:
URLURL TypeDescription CentralArticle
Goodson, Boyd M.0000-0001-6079-5077
Lu, George J.0000-0002-4689-9686
Shapiro, Mikhail G.0000-0002-0291-4215
Telkki, Ville-Veikko0000-0003-0846-6852
Schröder, Leif0000-0003-4901-0325
Additional Information:© 2016 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim. Issue online: 20 January 2017; Version of record online: 5 December 2016; Accepted manuscript online: 6 October 2016; Manuscript Received: 14 August 2016. The Hyperpolarised Lung Function Imaging Facility (HILF), within the Sir Peter Mansfield Magnetic Imaging Centre (SPMIC) at University of Nottingham, where the M.J.B, SS and IPH undertake research into novel functional MRI techniques, is the beneficiary of grants provided by UK’s Medical Research Council (MRC) and Engineering and Physical Sciences Research Council (EPSRC). MGS thanks Burroughs Wellcome Fund Career Award at the Scientific Interface, Human Frontiers Science Program # RGP0050, and Heritage Medical Research Institute for funding. AMC thanks NIH 1F32EB021840 career award. We thank the following award for funding support: NSF CHE-1416268 and CHE-1416432 (EYC, BMG, IVK, KVK), NIH 1R21EB018014 and 1R21EB020323 (EYC and BMG), DOD CDMRP BRP W81XWH-12-1-0159/BC112431 (EYC), PRMRP W81XWH-15-1-0271 and W81XWH-15-1-0272 (EYC, MSR, BMG), ExxonMobil Research and Engineering Company Knowledge Build (EYC). KVK, VVZ and IVK thank the Russian Science Foundation (grant 14–35–00020) for support of the MRI experiments. V.-V.T. acknowledges the Academy of Finland (grant numbers 289649 and 294027) for the financial support. Part of this work has been supported by the European Research Council under the European Community’s Seventh Framework Programme (FP7/2007-2013)/ERC grant agreement no. 242710 to L.S.) and the Leibniz Association (WGL; grant SAW-2011-FMP-2 to L.S.).
Group:Heritage Medical Research Institute
Funding AgencyGrant Number
Medical Research Council (MRC)UNSPECIFIED
Engineering and Physical Sciences Research Council (EPSRC)UNSPECIFIED
Burroughs Wellcome FundUNSPECIFIED
Human Frontiers Science ProgramRGP0050
Heritage Medical Research InstituteUNSPECIFIED
Department of Defense (DOD)CDMRP BRP W81XWH-12-1-0159/BC112431
Peer Reviewed Medical Research Program (PRMRP)W81XWH-15-1-0271
Peer Reviewed Medical Research Program (PRMRP)W81XWH-15-1-0272
ExxonMobil Research and Engineering CompanyUNSPECIFIED
Russian Science Foundation14-35-00020
Academy of Finland289649
Academy of Finland294027
European Research Council (ERC)242710
Leibniz AssociationSAW-2011-FMP-2
Subject Keywords:xenon-129; propane; NMR; gas; hyperpolarization; MRI
Issue or Number:4
PubMed Central ID:PMC5462469
Record Number:CaltechAUTHORS:20161018-095718409
Persistent URL:
Official Citation:D. A. Barskiy, A. M. Coffey, P. Nikolaou, D. M. Mikhaylov, B. M. Goodson, R. T. Branca, G. J. Lu, M. G. Shapiro, V.-V. Telkki, V. V. Zhivonitko, I. V. Koptyug, O. G. Salnikov, K. V. Kovtunov, V. I. Bukhtiyarov, M. S. Rosen, M. J. Barlow, S. Safavi, I. P. Hall, L. Schröder, E. Y. Chekmenev, Chem. Eur. J. 2017, 23, 725
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:71215
Deposited By: Tony Diaz
Deposited On:18 Oct 2016 17:24
Last Modified:11 Nov 2021 04:41

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