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The Organization, Expression, and Evolution of Antibody Genes and Other Multigene Families

Hood, L. and Campbell, J. H. and Elgin, S. C. R. (1975) The Organization, Expression, and Evolution of Antibody Genes and Other Multigene Families. Annual Review of Genetics, 9 . pp. 305-353. ISSN 0066-4197. http://resolver.caltech.edu/CaltechAUTHORS:20161019-131227879

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Abstract

Antibodies represent a complex eukaryotic system that has fascinated biologists for the past 75 years. The immune system has evolved novel and sophisticated strategies for dealing with extremely large amounts of information. These include strategies for information storage, information expression, and information evolution. Indeed, one of the driving forces in molecular immunology has been the attempt to formulate and analyze mechanisms responsible for the diversity of antibodies. Perhaps this consideration, more than any other, convinced many biologists that the immune system has evolved unique genetic strategies to protect the integrity of the vertebrate organism. We disagree with this viewpoint.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1146/annurev.ge.09.120175.001513DOIArticle
http://www.annualreviews.org/doi/abs/10.1146/annurev.ge.09.120175.001513PublisherArticle
ORCID:
AuthorORCID
Hood, L.0000-0001-7158-3678
Additional Information:© 1975 Annual Reviews. We thank Dr. John Smart for his participation in the early formative stages of this review. We also thank Drs. S. Rudikoff and E. Appella for the use of their unpublished sequences. The Caltech secretaries, as always, were superb. This work was supported by grants from the National Science Foundation, the National Institutes of Health, and the California Institute for Cancer Research. LH is the recipient of an NIH Research Career Development Award.
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NSFUNSPECIFIED
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California Institute for Cancer ResearchUNSPECIFIED
Record Number:CaltechAUTHORS:20161019-131227879
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:20161019-131227879
Official Citation:The Organization, Expression, and Evolution of Antibody Genes and Other Multigene Families L Hood, J H Campbell, and S C R Elgin Annual Review of Genetics, Vol. 9: 305 -353 (Volume publication date December 1975)
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:71280
Collection:CaltechAUTHORS
Deposited By: George Porter
Deposited On:19 Oct 2016 21:05
Last Modified:13 Feb 2019 18:06

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