A Caltech Library Service

Nanofabricated Neural Probes for Dense 3-D Recordings of Brain Activity

Rios, Gustavo and Lubenov, Evgueniy V. and Chi, Derrick and Roukes, Michael L. and Siapas, Athanassios G. (2016) Nanofabricated Neural Probes for Dense 3-D Recordings of Brain Activity. Nano Letters, 16 (11). pp. 6857-6862. ISSN 1530-6984. PMCID PMC5108031. doi:10.1021/acs.nanolett.6b02673.

[img] PDF (ACS Editors' Choice) - Published Version
See Usage Policy.

[img] PDF (Neural probe fabrication; heat dissipation analysis; surgical procedures and in vivo recording methods; histology; recording analysis and validation) - Supplemental Material
See Usage Policy.


Use this Persistent URL to link to this item:


Computations in brain circuits involve the coordinated activation of large populations of neurons distributed across brain areas. However, monitoring neuronal activity in the brain of intact animals with high temporal and spatial resolution has remained a technological challenge. Here we address this challenge by developing dense, three-dimensional (3-D) electrode arrays for electrophysiology. The 3-D arrays constitute the front-end of a modular and configurable system architecture that enables monitoring neuronal activity with unprecedented scale and resolution.

Item Type:Article
Related URLs:
URLURL TypeDescription Information CentralArticle
Lubenov, Evgueniy V.0000-0002-1099-944X
Roukes, Michael L.0000-0002-2916-6026
Siapas, Athanassios G.0000-0001-8837-678X
Additional Information:© 2016 American Chemical Society. ACS Editors' Choice - This is an open access article published under an ACS AuthorChoice License, which permits copying and redistribution of the article or any adaptations for non-commercial purposes. Received: June 28, 2016. Revised: September 17, 2016. Publication Date (Web): October 21, 2016. Foundry fabrication was carried out at CEA/LETI, Grenoble under the aegis of the Alliance for Nanosystems VLSI; we especially thank Denis Renaud, Eric Rouchouze, and Hughes Metras for their help. We thank Jennifer Mok for histological processing of brains from the in vivo experiments. This work was supported by the Mathers Foundation, the Beckman Institute at Caltech, the Moore Foundation, and the NIH (1DP1OD008255/5DP1MH099907). Author Contributions: G.R. and E.V.L. contributed equally to this work. System architecture and specification: G.R., E.V.L., M.L.R., A.G.S.; component design: G.R., E.V.L.; component mask layout: G.R., E.V.L.; component fabrication prototyping: G.R., D.C.; component foundry fabrication: G.R., E.V.L., M.L.R., A.G.S.; system packaging: G.R., E.V.L.; system software development: E.V.L.; system benchtop evaluation: G.R., E.V.L.; system in vivo evaluation: G.R., E.V.L., A.G.S.; manuscript preparation and figure creation: G.R., E.V.L. with input from A.G.S., M.L.R., D.C. The authors declare no competing financial interest.
Group:Kavli Nanoscience Institute
Funding AgencyGrant Number
Mathers FoundationUNSPECIFIED
Caltech Beckman InstituteUNSPECIFIED
Gordon and Betty Moore FoundationUNSPECIFIED
Subject Keywords:Nanofabricated neural probes, high-density microelectrodes, 3-D scalable packaging, brain mapping
Issue or Number:11
PubMed Central ID:PMC5108031
Record Number:CaltechAUTHORS:20161024-104001467
Persistent URL:
Official Citation:Nanofabricated Neural Probes for Dense 3-D Recordings of Brain Activity Gustavo Rios, Evgueniy V. Lubenov, Derrick Chi, Michael L. Roukes, and Athanassios G. Siapas Nano Letters 2016 16 (11), 6857-6862 DOI: 10.1021/acs.nanolett.6b02673
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:71380
Deposited By: George Porter
Deposited On:24 Oct 2016 17:59
Last Modified:08 Apr 2022 18:35

Repository Staff Only: item control page