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Ultra-High-Field Magnetic Resonance Imaging of the Human Inner Ear at 11.7 Tesla

Thylur, David S. and Jacobs, Russell E. and Go, John L. and Toga, Arthur W. and Niparko, John K. (2017) Ultra-High-Field Magnetic Resonance Imaging of the Human Inner Ear at 11.7 Tesla. Otology and Neurotology, 38 (1). pp. 133-138. ISSN 1531-7129. PMCID PMC5154835.

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Objective: To evaluate the ability of ultra-high-field magnetic resonance imaging (UHF-MRI) at 11.7 T to visualize membranous structures of the human inner ear. Specimens: Three temporal bones were extracted from cadaveric human heads for use with small-bore UHF-MRI. Intervention: Ex vivo cadaveric temporal bone specimens were imaged using an 11.7 T magnetic resonance imaging (MRI) scanner via T1- and T2-weighted-imaging with and without contrast. Main Outcome Measure: Qualitative visualization of membranous components of the inner ear compared with reports of UHF-MRI at lower field strengths. Results: The membranous anatomy of the inner ear was superbly visualized at 11.7 T. In the cochlea, Reissner's membrane, the scala media, and the basilar membrane were clearly shown on the scan. In the vestibular labyrinth, the wedge-shaped crista ampullaris and the maculae of both the saccule and utricle were visible. Details of the endolymphatic sac and duct were also demonstrated. Conclusion: To our knowledge, this report presents the first images of the ex vivo human inner ear using 11.7 T UHF-MRI, offering near-histologic resolution. Increased field strength may be particularly useful when imaging the delicate membranous anatomy of the inner ear. Further research on the use of UHF-MRI in clinical and research settings could illuminate structural changes associated with inner ear disorders.

Item Type:Article
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URLURL TypeDescription CentralArticle
Jacobs, Russell E.0000-0002-1382-8486
Additional Information:© 2016 Otology & Neurotology, Inc.
Subject Keywords:11.7 Tesla, Cochlea, Inner ear, MRI, Ultra-high-field MRI, Vestibular labyrinth
Issue or Number:1
PubMed Central ID:PMC5154835
Record Number:CaltechAUTHORS:20161024-130229714
Persistent URL:
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:71393
Deposited By: Tony Diaz
Deposited On:24 Oct 2016 20:33
Last Modified:03 Oct 2019 16:07

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