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Molecular Imaging of Brain Tumors Using Liposomal Contrast Agents and Nanoparticles

Mehta, Arnav and Ghaghada, Ketan and Mukundan, Srinivasan (2016) Molecular Imaging of Brain Tumors Using Liposomal Contrast Agents and Nanoparticles. Magnetic Resonance Imaging Clinics of North America, 24 (4). pp. 751-763. ISSN 1064-9689. https://resolver.caltech.edu/CaltechAUTHORS:20161024-152257171

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Abstract

The advent of genomic, proteomic, and high-throughput screening technologies has made available many new targets for brain tumor imaging; however, target availability and accessibility need to be carefully considered when designing imaging probes. Nanoparticles, although largely still only used in preclinical studies, are a versatile tool for targeted imaging of physiologic and molecular aspects of brain tumors through many clinically used modalities. Liposomes can be used to transport diverse payloads in vivo, including contrast agents and drugs, and may be functionalized to increase circulation half-life and achieve targeting specificity. Polymeric, gold, and iron oxide nanoparticles have been used for diverse applications in preclinical studies; however, the utility of other methods, such as quantum dots and self-assembling DNA molecules, is yet to be established.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1016/j.mric.2016.06.004DOIArticle
http://www.sciencedirect.com/science/article/pii/S1064968916300447PublisherArticle
Additional Information:© 2016 Elsevier Inc. Available online 14 September 2016.
Subject Keywords:Molecular imaging; Molecular targeting; Brain tumor; Liposomes; Iron oxide nanoparticle; Gold nanoparticle
Issue or Number:4
Record Number:CaltechAUTHORS:20161024-152257171
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20161024-152257171
Official Citation:Arnav Mehta, Ketan Ghaghada, Srinivasan Mukundan Jr., Molecular Imaging of Brain Tumors Using Liposomal Contrast Agents and Nanoparticles, Magnetic Resonance Imaging Clinics of North America, Volume 24, Issue 4, November 2016, Pages 751-763, ISSN 1064-9689, http://dx.doi.org/10.1016/j.mric.2016.06.004. (http://www.sciencedirect.com/science/article/pii/S1064968916300447)
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:71408
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:24 Oct 2016 22:28
Last Modified:03 Oct 2019 16:07

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