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Second harmonic nanoparticles in imaging applications

Pu, Ye and Hsieh, Chia-Lung and Grange, Rachel and Yang, Xin and Papadopoulos, Ioannis and Choi, Jae-Woo and Psaltis, Demetri (2011) Second harmonic nanoparticles in imaging applications. In: Active Photonic Materials IV. Proceedings of SPIE. No.8095. Society of Photo-Optical Instrumentation Engineers , Bellingham, WA, Art. No. 80950E. ISBN 9780819487056.

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Nanocrystals with second harmonic response is a new class of nonlinear optical nanoprobes with dramatically different properties from fluorescent agents. Compared with two-photon fluorescence, second harmonic generation is an ultrafast, lossless, and coherent process. In particular, the absence of photobleaching and emission intermittency in the optical response of the second harmonic nanoparticles is likely to complement the fluorescent agents widely used today in many imaging applications. Furthermore, the coherent emission from the second harmonic generation process provides unique opportunities for the application of coherence domain techniques that are not available with fluorescent agents. We review the application of the second harmonic nanocrystals in imaging applications, especially those pertaining to biomedicine.

Item Type:Book Section
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Yang, Xin0000-0001-5111-2959
Additional Information:© 2011 SPIE.
Subject Keywords:nonlinear optics, second harmonic generation, nanocrystals, multiphoton imaging, two-photon microscopy, three-dimensional, molecular tagging, two-photon fluorescence
Series Name:Proceedings of SPIE
Issue or Number:8095
Record Number:CaltechAUTHORS:20161028-104354237
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Official Citation:Ye Pu ; Chia-Lung Hsieh ; Rachel Grange ; Xin Yang ; Ioannis Papadopoulos ; Jae-Woo Choi ; Demetri Psaltis; Second harmonic nanoparticles in imaging applications. Proc. SPIE 8095, Active Photonic Materials IV, 80950E (September 12, 2011); doi:10.1117/12.894567
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:71571
Deposited By: Tony Diaz
Deposited On:28 Oct 2016 20:36
Last Modified:09 Mar 2020 13:19

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