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Basic design and simulation of a SPECT microscope for in vivo stem cell imaging

Moats, Rex A. and Tang, Yang and Hugg, James W. and Meier, Dirk and Koos, David S. and Hartsough, Neal E. and Patt, Bradley E. and Wagenaar, Douglas J. (2011) Basic design and simulation of a SPECT microscope for in vivo stem cell imaging. In: Medical Imaging 2011: Physics of Medical Imaging. Proceedings of SPIE. No.7961. Society of Photo-Optical Instrumentation Engineers , Bellingham, WA, Art. No. 79614B. ISBN 978-0-8194-8503-8. https://resolver.caltech.edu/CaltechAUTHORS:20161028-135256492

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Abstract

The need to understand the behavior of individual stem cells at the various stages of their differentiation and to assess the resulting reparative action in pre-clinical model systems, which typically involves laboratory animals, provides the motivation for imaging of stem cells in vivo at high resolution. Our initial focus is to image cells and cellular events at single cell resolution in vivo in shallow tissues (few mm of intervening tissue) in laboratory mice and rates. In order to accomplish this goal we are building a SPECT-based microscope. We based our design on earlier theoretical work with near-field coded apertures and have adjusted the components of the system to meet the real-world demands of instrument construction and of animal imaging. Our instrumental design possesses a reasonable trade-off between field-of-view, sensitivity, and contrast performance (photon penetration). A layered gold aperture containing 100 pinholes and intended for use in coded aperture imaging application has been designed and constructed. A silicon detector connected to a TimePix readout from the CERN collaborative group was selected for use in our prototype microscope because of its ultra-high spatial and energy resolution capabilities. The combination of the source, aperture, and detector has been modeled and the coded aperture reconstruction of simulated sources is presented in this work.


Item Type:Book Section
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1117/12.878427DOIArticle
http://proceedings.spiedigitallibrary.org/proceeding.aspx?articleid=724034PublisherArticle
Additional Information:© 2011 SPIE. We would like to thank Dan Gazit, Gadi Pelled, Todd Peterson, Gunnar Maehlum, William Barber, and Roberto Accorsi. Funding from the California Institute for Regenerative Medicine (CIRM), Tools & Technologies I program, grant RT01-01027 is gratefully acknowledged.
Funders:
Funding AgencyGrant Number
California Institute for Regenerative Medicine (CIRM)RT01-01027
Series Name:Proceedings of SPIE
Issue or Number:7961
Record Number:CaltechAUTHORS:20161028-135256492
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20161028-135256492
Official Citation:Rex A. Moats ; Yang Tang ; James W. Hugg ; Dirk Meier ; David Koos ; Neal E. Hartsough ; Bradley E. Patt ; Douglas J. Wagenaar; Basic design and simulation of a SPECT microscope for in vivo stem cell imaging. Proc. SPIE 7961, Medical Imaging 2011: Physics of Medical Imaging, 79614B (March 16, 2011); doi:10.1117/12.878427
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:71584
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:31 Oct 2016 17:40
Last Modified:03 Oct 2019 16:09

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