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Field-based multiplex and quantitative assay platforms for diagnostics

Venkatasubbarao, Srivatsa and Dixon, C. Edward and Chipman, Russell and Scherer, Axel and Beshay, Manal and Kempen, Lothar U. and Sekhar, Jai Ganesh Chandra and Yan, Hong and Puccio, Ava and Okonkwo, David and McClain, Stephen and Gilbert, Noah and Vyawahare, Saurabh (2011) Field-based multiplex and quantitative assay platforms for diagnostics. In: Sensing Technologies for Global Health, Military Medicine, Disaster Response, and Environmental Monitoring; and Biometric Technology for Human Identification VIII. Proceedings of SPIE. No.8029. Society of Photo-Optical Instrumentation Engineers , Bellingham, WA, Art. No. 80290P. ISBN 978-0-8194-8603-5. https://resolver.caltech.edu/CaltechAUTHORS:20161028-140214165

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Abstract

The U.S. military has a continued interest in the development of handheld, field-usable sensors and test kits for a variety of diagnostic applications, such as traumatic brain injury (TBI) and infectious diseases. Field-use presents unique challenges for biosensor design, both for the readout unit and for the biological assay platform. We have developed robust biosensor devices that offer ultra-high sensitivity and also meet field-use needs. The systems under development include a multiplexed quantitative lateral flow test strip for TBI diagnostics, a field test kit for the diagnosis of pathogens endemic to the Middle East, and a microfluidic assay platform with a label-free reader for performing complex biological automated assays in the field.


Item Type:Book Section
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1117/12.886661DOIArticle
http://proceedings.spiedigitallibrary.org/proceeding.aspx?articleid=1264674PublisherArticle
Additional Information:© 2011 SPIE. This work was funded by support from an Army SBIR contract (Contract # W81XWH07-C-0031) and an Air Force SBIR Contract (FA8650-07-C-6757). The author is indebted to project technical monitors Dr. Madhusoodana Nambiar and Dr. Camilla Mauzy for their suggestions and support in the development of this work.
Funders:
Funding AgencyGrant Number
Army Research Office (ARO)W81XWH07-C-0031
Air Force Office of Scientific Research (AFOSR)FA8650-07-C-6757
Subject Keywords:lateral flow immunoassay, dipstick assay, lateral flow test strip, field-based diagnostics, microfluidic chips, labelless detection, traumatic brain injury
Series Name:Proceedings of SPIE
Issue or Number:8029
Record Number:CaltechAUTHORS:20161028-140214165
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20161028-140214165
Official Citation:Srivatsa Venkatasubbarao ; C. Edward Dixon ; Russell Chipman ; Axel Scherer ; Manal Beshay ; Lothar U. Kempen ; Jai Ganesh Chandra Sekhar ; Hong Yan ; Ava Puccio ; David Okonkwo ; Stephen McClain ; Noah Gilbert ; Saurabh Vyawahare; Field-based multiplex and quantitative assay platforms for diagnostics. Proc. SPIE 8029, Sensing Technologies for Global Health, Military Medicine, Disaster Response, and Environmental Monitoring; and Biometric Technology for Human Identification VIII, 80290P (May 17, 2011); doi:10.1117/12.886661
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:71585
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:31 Oct 2016 17:38
Last Modified:03 Oct 2019 16:09

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