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Visualization of human retinal micro-capillaries with phase contrast high-speed optical coherence tomography

Kim, Dae Yu and Fingler, Jeff and Werner, John S. and Schwartz, Daniel M. and Fraser, Scott E. and Zawadzki, Robert J. (2011) Visualization of human retinal micro-capillaries with phase contrast high-speed optical coherence tomography. In: Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XV. Proceedings of SPIE. No.7889. Society of Photo-Optical Instrumentation Engineers , Bellingham, WA, Art. No. 78890H. ISBN 978-0-81948-426-0. http://resolver.caltech.edu/CaltechAUTHORS:20161028-145540710

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Abstract

We present high-speed Fourier-domain optical coherence tomography (Fd-OCT) with the phase variance based motion contrast method for visualizing retinal micro-circulation in vivo. This technique allows non-invasive visualization of a two-dimensional retinal perfusion map and concurrent volumetric morphology of retinal microvasculature with high sensitivity. The high-speed acquisition rate at 125kHz A-scans enables reduction of motion artifacts with increased scanning area if compared to previously reported results. Several scanning schemes with different sampling densities and scanning areas are evaluated to find optimal parameters for in vivo imaging. In order to evaluate this technique, we compare OCT micro-capillary imaging using the phase variance technique with fundus fluorescein angiography (FA). Additionally, volumetric visualization of blood flow for a normal subject is presented.


Item Type:Book Section
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1117/12.873896DOIArticle
http://proceedings.spiedigitallibrary.org/proceeding.aspx?articleid=732630PublisherArticle
ORCID:
AuthorORCID
Fraser, Scott E.0000-0002-5739-4026
Additional Information:© 2011 SPIE. The authors would like to thank Suman Pilli, Susan Garcia for help with OCT data acquisition. This research was supported by the Howard Hughes Medical Institute (HHMI) Med-into-Grad Initiative, National Eye Institute (EY 014743), Research to Prevent Blindness (RPB), Beckman Institute, and That Man May See Foundation.
Funders:
Funding AgencyGrant Number
Howard Hughes Medical Institute (HHMI)UNSPECIFIED
National Eye InstituteEY 014743
Research to Prevent BlindnessUNSPECIFIED
Caltech Beckman InstituteUNSPECIFIED
That Man May See FoundationUNSPECIFIED
Subject Keywords:Optical coherence tomography; Phase contrast technique; Imaging system; Medical optics instrumentation
Record Number:CaltechAUTHORS:20161028-145540710
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:20161028-145540710
Official Citation:Dae Yu Kim ; Jeff Fingler ; John S. Werner ; Daniel M. Schwartz ; Scott E. Fraser ; Robert J. Zawadzki; Visualization of human retinal micro-capillaries with phase contrast high-speed optical coherence tomography. Proc. SPIE 7889, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XV, 78890H (February 15, 2011); doi:10.1117/12.873896
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:71589
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:31 Oct 2016 17:26
Last Modified:31 Oct 2016 17:26

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