Cong, Wenxiang and Durairaj, Kumar and Wang, Lihong V. and Wang, Ge (2006) A Born-type approximation method for bioluminescence tomography. Medical Physics, 33 (3). pp. 679-686. ISSN 0094-2405. doi:10.1118/1.2168293. https://resolver.caltech.edu/CaltechAUTHORS:20161102-154340931
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Abstract
In this paper, we present a Born-type approximation method for bioluminescence tomography (BLT), which is to reconstruct an internal bioluminescent source from the measured bioluminescent signal on the external surface of a small animal. Based on the diffusion approximation for the photon propagation in biological tissue, this BLT method utilizes the Green function to establish a linear relationship between the measured bioluminescent signal and the internal bioluminescent source distribution. The Green function can be modified to describe a heterogeneous medium with an arbitrary boundary using the Born approximation. The BLT reconstruction is formulated in a linear least-squares optimization framework with simple bounds constraint. The performance of this method is evaluated in numerical simulation and phantom experiments.
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| Additional Information: | © 2006 American Association of Physicists in Medicine. Received 21 October 2004; revised 25 December 2005; accepted for publication 28 December 2005; published 21 February 2006. This work is supported by NIH/NIBIB Grant No. EB001685. | |||||||||
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| Subject Keywords: | bioluminescence tomography (BLT), diffusion approximation, Green function, Born approximation | |||||||||
| Issue or Number: | 3 | |||||||||
| DOI: | 10.1118/1.2168293 | |||||||||
| Record Number: | CaltechAUTHORS:20161102-154340931 | |||||||||
| Persistent URL: | https://resolver.caltech.edu/CaltechAUTHORS:20161102-154340931 | |||||||||
| Official Citation: | A Born-type approximation method for bioluminescence tomography Cong, Wenxiang and Durairaj, Kumar and Wang, Lihong V. and Wang, Ge, Medical Physics, 33, 679-686 (2006), DOI:http://dx.doi.org/10.1118/1.2168293 | |||||||||
| Usage Policy: | No commercial reproduction, distribution, display or performance rights in this work are provided. | |||||||||
| ID Code: | 71695 | |||||||||
| Collection: | CaltechAUTHORS | |||||||||
| Deposited By: | Tony Diaz | |||||||||
| Deposited On: | 02 Nov 2016 23:26 | |||||||||
| Last Modified: | 11 Nov 2021 04:49 |
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