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A Born-type approximation method for bioluminescence tomography

Cong, Wenxiang and Durairaj, Kumar and Wang, Lihong V. and Wang, Ge (2006) A Born-type approximation method for bioluminescence tomography. Medical Physics, 33 (3). pp. 679-686. ISSN 0094-2405. https://resolver.caltech.edu/CaltechAUTHORS:20161102-154340931

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Abstract

In this paper, we present a Born-type approximation method for bioluminescence tomography (BLT), which is to reconstruct an internal bioluminescent source from the measured bioluminescent signal on the external surface of a small animal. Based on the diffusion approximation for the photon propagation in biological tissue, this BLT method utilizes the Green function to establish a linear relationship between the measured bioluminescent signal and the internal bioluminescent source distribution. The Green function can be modified to describe a heterogeneous medium with an arbitrary boundary using the Born approximation. The BLT reconstruction is formulated in a linear least-squares optimization framework with simple bounds constraint. The performance of this method is evaluated in numerical simulation and phantom experiments.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1118/1.2168293DOIArticle
http://scitation.aip.org/content/aapm/journal/medphys/33/3/10.1118/1.2168293PublisherArticle
ORCID:
AuthorORCID
Wang, Lihong V.0000-0001-9783-4383
Additional Information:© 2006 American Association of Physicists in Medicine. Received 21 October 2004; revised 25 December 2005; accepted for publication 28 December 2005; published 21 February 2006. This work is supported by NIH/NIBIB Grant No. EB001685.
Funders:
Funding AgencyGrant Number
NIHEB001685
Subject Keywords:bioluminescence tomography (BLT), diffusion approximation, Green function, Born approximation
Issue or Number:3
Record Number:CaltechAUTHORS:20161102-154340931
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20161102-154340931
Official Citation:A Born-type approximation method for bioluminescence tomography Cong, Wenxiang and Durairaj, Kumar and Wang, Lihong V. and Wang, Ge, Medical Physics, 33, 679-686 (2006), DOI:http://dx.doi.org/10.1118/1.2168293
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:71695
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:02 Nov 2016 23:26
Last Modified:03 Oct 2019 16:10

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