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The Central Nervous System and the Gut Microbiome

Sharon, Gil and Sampson, Timothy R. and Geschwind, Daniel H. and Mazmanian, Sarkis K. (2016) The Central Nervous System and the Gut Microbiome. Cell, 167 (4). pp. 915-932. ISSN 0092-8674. PMCID PMC5127403. http://resolver.caltech.edu/CaltechAUTHORS:20161107-090306622

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Abstract

Neurodevelopment is a complex process governed by both intrinsic and extrinsic signals. While historically studied by researching the brain, inputs from the periphery impact many neurological conditions. Indeed, emerging data suggest communication between the gut and the brain in anxiety, depression, cognition, and autism spectrum disorder (ASD). The development of a healthy, functional brain depends on key pre- and post-natal events that integrate environmental cues, such as molecular signals from the gut. These cues largely originate from the microbiome, the consortium of symbiotic bacteria that reside within all animals. Research over the past few years reveals that the gut microbiome plays a role in basic neurogenerative processes such as the formation of the blood-brain barrier, myelination, neurogenesis, and microglia maturation and also modulates many aspects of animal behavior. Herein, we discuss the biological intersection of neurodevelopment and the microbiome and explore the hypothesis that gut bacteria are integral contributors to development and function of the nervous system and to the balance between mental health and disease.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1016/j.cell.2016.10.027DOIArticle
http://www.sciencedirect.com/science/article/pii/S0092867416314477PublisherArticle
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5127403/PubMed CentralArticle
ORCID:
AuthorORCID
Mazmanian, Sarkis K.0000-0003-2713-1513
Additional Information:© 2016 Elsevier Inc. The authors apologize to colleagues whose work could not be included in this Review. We thank Drs. Hiutung Chu and Wei-li Wu, as well as Carly Stewart for critical reading of this manuscript. The authors are supported by the Meixner Postdoctoral Fellowship in Translational Research (to G.S.) and the Larry L. Hillblom Foundation Postdoctoral Fellowship (to T.R.S.). Related research in the Mazmanian laboratory is funded by grants from the NIH (MH100556, DK078938, GM099535, and NS085910), the Department of Defense, the Heritage Medical Research Institute, and the Simons Foundation. Related research in the Geschwind lab is supported by NIMH grants (HD055784, MH100027, MH110927, and MH1064382), and the Simons Foundation.
Group:Heritage Medical Research Institute
Funders:
Funding AgencyGrant Number
Autism SpeaksUNSPECIFIED
Larry L. Hillblom FoundationUNSPECIFIED
NIHMH100556
NIHDK078938
NIHGM099535
NIHNS085910
Department of DefenseUNSPECIFIED
Heritage Medical Research InstituteUNSPECIFIED
Simons FoundationUNSPECIFIED
NIHHD055784
NIHMH100027
NIHMH110927
NIHMH1064382
PubMed Central ID:PMC5127403
Record Number:CaltechAUTHORS:20161107-090306622
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:20161107-090306622
Official Citation:Gil Sharon, Timothy R. Sampson, Daniel H. Geschwind, Sarkis K. Mazmanian, The Central Nervous System and the Gut Microbiome, Cell, Volume 167, Issue 4, 3 November 2016, Pages 915-932, ISSN 0092-8674, http://dx.doi.org/10.1016/j.cell.2016.10.027. (http://www.sciencedirect.com/science/article/pii/S0092867416314477)
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:71760
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:07 Nov 2016 19:27
Last Modified:10 Jul 2017 22:36

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