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Microbuckling of Fibrous Matrices Enables Long Range Cell Mechanosensing

Burkel, Brian and Lesman, Ayelet and Rosakis, Phoebus and Tirrell, David A. and Ravichandran, Guruswami and Notbohm, Jacob (2016) Microbuckling of Fibrous Matrices Enables Long Range Cell Mechanosensing. In: Mechanics of Biological Systems and Materials. Vol.6. Springer , Cham, pp. 135-141. ISBN 978-3-319-41350-1. https://resolver.caltech.edu/CaltechAUTHORS:20161108-141109524

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Abstract

When biological cells migrate, divide, and invade, they push and pull on individual fibers of the matrix surrounding them. The resulting fiber displacements are neither uniform nor smooth; rather, displacements localize to form dense fibrous bands that span from one cell to another. It is thought that these bands may be a mechanism by which cells can sense their neighbors, but this hypothesis remains untested, because the mechanism for band formation remains unknown. Using digital volume correlation, we measure the displacements induced by contractile cells embedded in a fibrous matrix. We find that cell-induced displacements propagate over a longer range than predicted by linear elasticity. To explain the long-range propagation of displacements, we consider the effect of buckling of individual matrix fibers, which generates a nonlinear stress-strain relationship. We show that fiber buckling is the mechanism that causes the displacements to propagate over a long range and the bands to form between nearby cells. The results thus show that buckling of individual fibers provides a mechanism by which cells may sense their distant neighbors mechanically.


Item Type:Book Section
Related URLs:
URLURL TypeDescription
https://doi.org/10.1007/978-3-319-41351-8_19DOIArticle
ORCID:
AuthorORCID
Tirrell, David A.0000-0003-3175-4596
Ravichandran, Guruswami0000-0002-2912-0001
Additional Information:© 2017 The Society for Experimental Mechanics, Inc. First Online: 21 September 2016. This work was funded by grants from the National Science Foundation (Division of Materials Research 0520565 and 1206121) and from the California Institute for Regenerative Medicine (RB5-07398). J.N. was supported by the National Science Foundation Graduate Research Fellowship under Grant No. DGE-1144469. A.L. was supported in part by a Rothschild Foundation fellowship.
Group:GALCIT
Funders:
Funding AgencyGrant Number
NSFDMR-0520565
NSFDMR-1206121
California Institute for Regenerative MedicineRB5-07398
NSF Graduate Research FellowshipDGE-1144469
Rothschild Foundation FellowshipUNSPECIFIED
Subject Keywords:Extracellular matrix – Mechanosensing – Fiber buckling – DVC – Traction force microscopy
Record Number:CaltechAUTHORS:20161108-141109524
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20161108-141109524
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:71817
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:09 Nov 2016 00:44
Last Modified:09 Mar 2020 13:19

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