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Imaging acute thermal burns by photoacoustic microscopy

Zhang, Hao F. and Maslov, Konstantin and Stoica, George and Wang, Lihong V. (2006) Imaging acute thermal burns by photoacoustic microscopy. Journal of Biomedical Optics, 11 (5). Art. No. 054033. ISSN 1083-3668. https://resolver.caltech.edu/CaltechAUTHORS:20161109-152329007

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Abstract

The clinical significance of a burn depends on the percentage of total body involved and the depth of the burn. Hence a noninvasive method that is able to evaluate burn depth would be of great help in clinical evaluation. To this end, photoacoustic microscopy is used to determine the depth of acute thermal burns by imaging the total hemoglobin concentration in the blood that accumulates along the boundaries of injuries as a result of thermal damage to the vasculature. We induce acute thermal burns in vivo on pig skin with cautery. Photoacoustic images of the burns are acquired after skin excision. In a burn treated at 175°C for 20s, the maximum imaged burn depth is 1.73±0.07mm. In burns treated at 150°C for 5, 10, 20, and 30s, respectively, the trend of increasing maximum burn depth with longer thermal exposure is demonstrated.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1117/1.2355667DOIArticle
http://biomedicaloptics.spiedigitallibrary.org/article.aspx?articleid=1102317PublisherArticle
ORCID:
AuthorORCID
Maslov, Konstantin0000-0003-3408-8840
Stoica, George0000-0001-8071-4828
Wang, Lihong V.0000-0001-9783-4383
Additional Information:© 2006 SPIE. Received May 18, 2006; Revised July 17, 2006; Accepted July 19, 2006; Published September 21, 2006; Online September 21, 2006. We thank Dr. Geng Ku and Xueyi Xie for experimental assistance. This project is sponsored by National Institutes of Health grants R01 EB000712 and R01 NS46214.
Funders:
Funding AgencyGrant Number
NIHR01 EB000712
NIHR01 NS46214
Subject Keywords:noninvasive imaging; photoacoustic imaging; partial-thickness burn; thermal injury
Issue or Number:5
Record Number:CaltechAUTHORS:20161109-152329007
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20161109-152329007
Official Citation:Zhang HF, Maslov K, Stoica G, Wang LV; Imaging acute thermal burns by photoacoustic microscopy. J. Biomed. Opt. 0001;11(5):054033-054033-5
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:71897
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:09 Nov 2016 23:29
Last Modified:03 Mar 2020 13:13

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