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Improved in vivo photoacoustic microscopy based on a virtual-detector concept

Li, Meng-Lin and Zhang, Hao F. and Maslov, Konstantin and Stoica, George and Wang, Lihong V. (2006) Improved in vivo photoacoustic microscopy based on a virtual-detector concept. Optics Letters, 31 (4). pp. 474-476. ISSN 0146-9592. https://resolver.caltech.edu/CaltechAUTHORS:20161109-153322464

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Abstract

Recently an in vivo high-resolution backward-mode photoacoustic microscope was developed that shows potential for applications in dermatology and related cancer research. However, the limited depth of focus of the large-numerical-aperture (NA) ultrasonic lens employed in this system causes the image quality to deteriorate significantly in the out-of-focus region. To solve this problem, we devised and explored, for the first time to our knowledge, a virtual-detector-based synthetic-aperture focusing technique, combined with coherence weighting, for photoacoustic microscopy with such a large-NA transducer. Images of phantoms show that the proposed technique improves the −6 dB−6 dB lateral resolution from 49–379 to 46–53 


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1364/OL.31.000474DOIArticle
https://www.osapublishing.org/ol/abstract.cfm?uri=ol-31-4-474PublisherArticle
ORCID:
AuthorORCID
Maslov, Konstantin0000-0003-3408-8840
Stoica, George0000-0001-8071-4828
Wang, Lihong V.0000-0001-9783-4383
Additional Information:© 2006 Optical Society of America. Received July 18, 2005; revised October 18, 2005; accepted November 4, 2005; posted November 10, 2005 (Doc. ID 63562). This project was sponsored by National Institutes of Health grants R01 EB000712 and R01 NS46214.
Funders:
Funding AgencyGrant Number
NIHR01 EB000712
NIHR01 NS46214
Issue or Number:4
Classification Code:OCIS codes: 170.3880, 170.5120, 180.5810
Record Number:CaltechAUTHORS:20161109-153322464
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20161109-153322464
Official Citation:Meng-Lin Li, Hao F. Zhang, Konstantin Maslov, George Stoica, and Lihong V. Wang, "Improved in vivo photoacoustic microscopy based on a virtual-detector concept," Opt. Lett. 31, 474-476 (2006)
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:71898
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:09 Nov 2016 23:51
Last Modified:03 Mar 2020 13:13

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