Li, Meng-Lin and Zhang, Hao F. and Maslov, Konstantin and Stoica, George and Wang, Lihong V. (2006) Improved in vivo photoacoustic microscopy based on a virtual-detector concept. Optics Letters, 31 (4). pp. 474-476. ISSN 0146-9592. doi:10.1364/OL.31.000474. https://resolver.caltech.edu/CaltechAUTHORS:20161109-153322464
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Abstract
Recently an in vivo high-resolution backward-mode photoacoustic microscope was developed that shows potential for applications in dermatology and related cancer research. However, the limited depth of focus of the large-numerical-aperture (NA) ultrasonic lens employed in this system causes the image quality to deteriorate significantly in the out-of-focus region. To solve this problem, we devised and explored, for the first time to our knowledge, a virtual-detector-based synthetic-aperture focusing technique, combined with coherence weighting, for photoacoustic microscopy with such a large-NA transducer. Images of phantoms show that the proposed technique improves the −6 dB−6 dB lateral resolution from 49–379 to 46–53
| Item Type: | Article | |||||||||
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| Additional Information: | © 2006 Optical Society of America. Received July 18, 2005; revised October 18, 2005; accepted November 4, 2005; posted November 10, 2005 (Doc. ID 63562). This project was sponsored by National Institutes of Health grants R01 EB000712 and R01 NS46214. | |||||||||
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| Issue or Number: | 4 | |||||||||
| Classification Code: | OCIS codes: 170.3880, 170.5120, 180.5810 | |||||||||
| DOI: | 10.1364/OL.31.000474 | |||||||||
| Record Number: | CaltechAUTHORS:20161109-153322464 | |||||||||
| Persistent URL: | https://resolver.caltech.edu/CaltechAUTHORS:20161109-153322464 | |||||||||
| Official Citation: | Meng-Lin Li, Hao F. Zhang, Konstantin Maslov, George Stoica, and Lihong V. Wang, "Improved in vivo photoacoustic microscopy based on a virtual-detector concept," Opt. Lett. 31, 474-476 (2006) | |||||||||
| Usage Policy: | No commercial reproduction, distribution, display or performance rights in this work are provided. | |||||||||
| ID Code: | 71898 | |||||||||
| Collection: | CaltechAUTHORS | |||||||||
| Deposited By: | Tony Diaz | |||||||||
| Deposited On: | 09 Nov 2016 23:51 | |||||||||
| Last Modified: | 11 Nov 2021 04:52 |
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