A Caltech Library Service

Improved in vivo photoacoustic microscopy based on a virtual-detector concept

Li, Meng-Lin and Zhang, Hao F. and Maslov, Konstantin and Stoica, George and Wang, Lihong V. (2006) Improved in vivo photoacoustic microscopy based on a virtual-detector concept. Optics Letters, 31 (4). pp. 474-476. ISSN 0146-9592. doi:10.1364/OL.31.000474.

[img] PDF - Published Version
See Usage Policy.


Use this Persistent URL to link to this item:


Recently an in vivo high-resolution backward-mode photoacoustic microscope was developed that shows potential for applications in dermatology and related cancer research. However, the limited depth of focus of the large-numerical-aperture (NA) ultrasonic lens employed in this system causes the image quality to deteriorate significantly in the out-of-focus region. To solve this problem, we devised and explored, for the first time to our knowledge, a virtual-detector-based synthetic-aperture focusing technique, combined with coherence weighting, for photoacoustic microscopy with such a large-NA transducer. Images of phantoms show that the proposed technique improves the −6 dB−6 dB lateral resolution from 49–379 to 46–53 

Item Type:Article
Related URLs:
URLURL TypeDescription
Maslov, Konstantin0000-0003-3408-8840
Stoica, George0000-0001-8071-4828
Wang, Lihong V.0000-0001-9783-4383
Additional Information:© 2006 Optical Society of America. Received July 18, 2005; revised October 18, 2005; accepted November 4, 2005; posted November 10, 2005 (Doc. ID 63562). This project was sponsored by National Institutes of Health grants R01 EB000712 and R01 NS46214.
Funding AgencyGrant Number
NIHR01 EB000712
NIHR01 NS46214
Issue or Number:4
Classification Code:OCIS codes: 170.3880, 170.5120, 180.5810
Record Number:CaltechAUTHORS:20161109-153322464
Persistent URL:
Official Citation:Meng-Lin Li, Hao F. Zhang, Konstantin Maslov, George Stoica, and Lihong V. Wang, "Improved in vivo photoacoustic microscopy based on a virtual-detector concept," Opt. Lett. 31, 474-476 (2006)
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:71898
Deposited By: Tony Diaz
Deposited On:09 Nov 2016 23:51
Last Modified:11 Nov 2021 04:52

Repository Staff Only: item control page