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Noninvasive imaging of hemoglobin concentration and oxygenation in the rat brain using high-resolution photoacoustic tomography

Wang, Xueding and Xie, Xueyi and Ku, Geng and Wang, Lihong V. and Stoica, George (2006) Noninvasive imaging of hemoglobin concentration and oxygenation in the rat brain using high-resolution photoacoustic tomography. Journal of Biomedical Optics, 11 (2). Art. No. 024015. ISSN 1083-3668. https://resolver.caltech.edu/CaltechAUTHORS:20161118-103745094

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Abstract

Simultaneous transcranial imaging of two functional parameters, the total concentration of hemoglobin and the hemoglobin oxygen saturation, in the rat brain in vivo is realized noninvasively using laser-based photoacoustic tomography (PAT). As in optical diffusion spectroscopy, PAT can assess the optical absorption of endogenous chromophores, e.g., oxygenated and deoxygenated hemoglobins, at multiple optical wavelengths. However, PAT can provide high spatial resolution because its resolution is diffraction-limited by photoacoustic signals rather than by optical diffusion. Laser pulses at two wavelengths are used sequentially to acquire photoacoustic images of the vasculature in the cerebral cortex of a rat brain through the intact skin and skull. The distributions of blood volume and blood oxygenation in the cerebral cortical venous vessels, altered by systemic physiological modulations including hyperoxia, normoxia, and hypoxia, are visualized successfully with satisfactory spatial resolution. This technique, with its prominent sensitivity to endogenous contrast, can potentially contribute to the understanding of the interrelationship between neural, hemodynamic, and metabolic activities in the brain.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1117/1.2192804DOIArticle
http://biomedicaloptics.spiedigitallibrary.org/article.aspx?articleid=1028943PublisherArticle
ORCID:
AuthorORCID
Wang, Lihong V.0000-0001-9783-4383
Stoica, George0000-0001-8071-4828
Additional Information:© 2006 SPIE. Paper 05240RR received Aug. 17, 2005; revised manuscript received Dec. 22, 2005; accepted for publication Dec. 22, 2005; published online May 3, 2006. This study was sponsored in part by the National Institutes of Health (NIH), the Department of Defense (DOD), and the Texas Advanced Research Program.
Funders:
Funding AgencyGrant Number
NIHUNSPECIFIED
Department of DefenseUNSPECIFIED
Texas Advanced Research ProgramUNSPECIFIED
Subject Keywords:photoacoustic tomography; spectroscopic imaging; hemoglobin oxygen saturation; total concentration of hemoglobin; neuroimaging
Issue or Number:2
Record Number:CaltechAUTHORS:20161118-103745094
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20161118-103745094
Official Citation:Wang X, Xie X, Ku G, Wang LV, Stoica G; Noninvasive imaging of hemoglobin concentration and oxygenation in the rat brain using high-resolution photoacoustic tomography. J. Biomed. Opt. 0001;11(2):024015-024015-9
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:72156
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:18 Nov 2016 18:46
Last Modified:03 Mar 2020 13:13

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