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Deeply penetrating photoacoustic tomography in biological tissues enhanced with an optical contrast agent

Ku, Geng and Wang, Lihong V. (2005) Deeply penetrating photoacoustic tomography in biological tissues enhanced with an optical contrast agent. Optics Letters, 30 (5). pp. 507-509. ISSN 0146-9592. doi:10.1364/OL.30.000507. https://resolver.caltech.edu/CaltechAUTHORS:20161118-125233243

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Abstract

Photoacoustic tomography (PAT) in a circular scanning configuration was developed to image deeply embedded optical heterogeneity in biological tissues. While the optical penetration was maximized with near-infrared laser pulses of 800-nm wavelength, the optical contrast was enhanced by Indocyanine Green (ICG) dye whose absorption peak matched the laser wavelength. This optimized PAT was able to image objects embedded at depths of as much as 5.2 cm, 6.2 times the 1/e optical penetration depth, in chicken breast muscle at a resolution of <780 µm and a sensitivity of <7 pmol of ICG in blood. The resolution was found to deteriorate slowly with increasing imaging depth. The effects of detection bandwidth on the quality of images acquired simultaneously by four different ultrasonic transducers are described.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1364/OL.30.000507DOIArticle
https://www.osapublishing.org/ol/abstract.cfm?uri=ol-30-5-507PublisherArticle
ORCID:
AuthorORCID
Wang, Lihong V.0000-0001-9783-4383
Additional Information:© 2005 Optical Society of America. Received September 15, 2004. We thank G. Stoica for assistance with blood samples and X. Xie, X. Wang, M. Sivaramakrishnan, and K. Song for laboratory assistance. This study is sponsored in part by National Institutes of Health grants R01 EB000712 and R01 NS46214 and by Texas Advanced Technology Program grant 000512-0063-2001.
Funders:
Funding AgencyGrant Number
NIHR01 EB000712
NIHR01 NS46214
Texas Advanced Technology Program000512-0063-2001
Issue or Number:5
Classification Code:OCIS codes: 170.5120, 170.1470, 170.3880, 170.0100
DOI:10.1364/OL.30.000507
Record Number:CaltechAUTHORS:20161118-125233243
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20161118-125233243
Official Citation:Geng Ku and Lihong V. Wang, "Deeply penetrating photoacoustic tomography in biological tissues enhanced with an optical contrast agent," Opt. Lett. 30, 507-509 (2005)
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:72164
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:18 Nov 2016 22:21
Last Modified:11 Nov 2021 04:57

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