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Imaging of high-intensity focused ultrasound-induced lesions in soft biological tissue using thermoacoustic tomography

Jin, Xing and Xu, Yuan and Wang, Lihong V. and Fang, Yuncai R. and Zanelli, Claudio I. and Howard, Samuel M. (2005) Imaging of high-intensity focused ultrasound-induced lesions in soft biological tissue using thermoacoustic tomography. Medical Physics, 32 (1). pp. 5-11. ISSN 0094-2405. http://resolver.caltech.edu/CaltechAUTHORS:20161118-131815944

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Abstract

An imaging technology, thermoacoustic tomograpy (TAT), was applied to the visualization of high-intensity focused ultrasound (HIFU)-induced lesions. A single, spherically focused ultrasonic transducer, operating at a central frequency of approximately 4 MHz, was used to generate a HIFU field in fresh porcine muscle.Microwave pulses from a 3-GHz microwave generator were then employed to generate thermoacoustic sources in this tissue sample. The thermoacoustic signals were detected by an unfocused ultrasonic transducer that was scanned around the sample. To emphasize the boundaries between the lesion and its surrounding tissue, a local-tomography-type reconstruction method was applied to reconstruct the TAT images of the lesions. Good contrast was obtained between the lesion and the tissue surrounding it. Gross pathologic photographs of the tissue samples confirmed the TAT images.This work demonstrates that TAT may potentially be used to image HIFU-induced lesions in biological tissues.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1118/1.1829403DOIArticle
http://scitation.aip.org/content/aapm/journal/medphys/32/1/10.1118/1.1829403PublisherArticle
ORCID:
AuthorORCID
Xu, Yuan0000-0001-9326-2197
Wang, Lihong V.0000-0001-9783-4383
Additional Information:© 2005 American Association of Physicists in Medicine. Received 27 July 2004; Revised 15 October 2004; Accepted 19 October 2004; Published online 10 December 2004.
Subject Keywords:thermoacoustic tomography, high-intensity focused ultrasound, HIFU, treatment monitoring, microwave contrast
Record Number:CaltechAUTHORS:20161118-131815944
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:20161118-131815944
Official Citation:Imaging of high-intensity focused ultrasound-induced lesions in soft biological tissue using thermoacoustic tomography Jin, Xing and Xu, Yuan and Wang, Lihong V. and Fang, Yuncai R. and Zanelli, Claudio I. and Howard, Samuel M., Medical Physics, 32, 5-11 (2005), DOI:http://dx.doi.org/10.1118/1.1829403
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:72167
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:18 Nov 2016 22:19
Last Modified:18 Nov 2016 22:19

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