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Imaging of tumor angiogenesis in rat brains in vivo by photoacoustic tomography

Ku, Geng and Wang, Xueding and Xie, Xueyi and Stoica, George and Wang, Lihong V. (2005) Imaging of tumor angiogenesis in rat brains in vivo by photoacoustic tomography. Applied Optics, 44 (5). pp. 770-775. ISSN 0003-6935. doi:10.1364/AO.44.000770.

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Green laser pulses at a wavelength of 532 nm from a Q-switched Nd:YAG laser were employed as irradiation sources for photoacoustic tomography (PAT). The vascular structure of the brain was imaged clearly, with optimal contrast, because blood has strong absorption near this wavelength. The photoacoustic images of rat brain tumors in this study clearly reveal the angiogenesis that is associated with tumors. Brain tumors can be identified based on the distorted vascular architecture of brain tumorigenesis and related vascular changes, such as hemorrhage. This research demonstrates that PAT can potentially provide a powerful tool for small-animal biological research.

Item Type:Article
Related URLs:
URLURL TypeDescription
Stoica, George0000-0001-8071-4828
Wang, Lihong V.0000-0001-9783-4383
Additional Information:© 2005 Optical Society of America. Received 19 July 2004; revised manuscript received 7 October 2004; accepted 20 October 2004. This study is sponsored by the National Institutes of Health (grants R01 NS46214-01 and R01 EB000712).
Funding AgencyGrant Number
NIHR01 NS46214-01
NIHR01 EB000712
Issue or Number:5
Classification Code:OCIS codes: 170.5120, 170.3880, 170.0110
Record Number:CaltechAUTHORS:20161118-132318724
Persistent URL:
Official Citation:Geng Ku, Xueding Wang, Xueyi Xie, George Stoica, and Lihong V. Wang, "Imaging of tumor angiogenesis in rat brains in vivo by photoacoustic tomography," Appl. Opt. 44, 770-775 (2005)
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:72168
Deposited By: Tony Diaz
Deposited On:18 Nov 2016 22:18
Last Modified:11 Nov 2021 04:57

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