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Looking and listening to light: the evolution of whole-body photonic imaging

Ntziachristos, Vasilis and Ripoll, Jorge and Wang, Lihong V. and Weissleder, Ralph (2005) Looking and listening to light: the evolution of whole-body photonic imaging. Nature Biotechnology, 23 (3). pp. 313-320. ISSN 1087-0156. doi:10.1038/nbt1074. https://resolver.caltech.edu/CaltechAUTHORS:20161118-132914808

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Abstract

Optical imaging of live animals has grown into an important tool in biomedical research as advances in photonic technology and reporter strategies have led to widespread exploration of biological processes in vivo. Although much attention has been paid to microscopy, macroscopic imaging has allowed small-animal imaging with larger fields of view (from several millimeters to several centimeters depending on implementation). Photographic methods have been the mainstay for fluorescence and bioluminescence macroscopy in whole animals, but emphasis is shifting to photonic methods that use tomographic principles to noninvasively image optical contrast at depths of several millimeters to centimeters with high sensitivity and sub-millimeter to millimeter resolution. Recent theoretical and instrumentation advances allow the use of large data sets and multiple projections and offer practical systems for quantitative, three-dimensional whole-body images. For photonic imaging to fully realize its potential, however, further progress will be needed in refining optical inversion methods and data acquisition techniques.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1038/nbt1074DOIArticle
https://rdcu.be/b3Ax7PublisherFree ReadCube access
ORCID:
AuthorORCID
Wang, Lihong V.0000-0001-9783-4383
Additional Information:© 2005 Macmillan Publishers Limited. Published online: 4 March 2005. V.N. is supported in part by National Institutes of Health (NIH) grants RO1 EB 000750-1, 1-NO1-CO027105 and R33 CA 91807. J. Ripoll acknowledges support from EU Integrated Project "Molecular Imaging" LSHG-CT-2003-503259. R.W. is supported in part by NIH grants P50 CA86355, R24 CA92782, R33 CA091807, PO1 AI054904, PO1 CA69246 and grants from the Donald W. Reynolds Foundation and Siemens Medical Systems.
Funders:
Funding AgencyGrant Number
NIHRO1 EB 000750-1
NIH1-NO1-CO027105
NIHR33 CA 91807
European Research Council (ERC)LSHG-CT-2003-503259
NIHP50 CA86355
NIHR24 CA92782
NIHR33 CA091807
NIHPO1 AI054904
NIHPO1 CA69246
Donald W. Reynolds FoundationUNSPECIFIED
Siemens Medical SystemsUNSPECIFIED
Issue or Number:3
DOI:10.1038/nbt1074
Record Number:CaltechAUTHORS:20161118-132914808
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20161118-132914808
Official Citation:Looking and listening to light: the evolution of whole-body photonic imaging Vasilis Ntziachristos, Jorge Ripoll, Lihong V Wang & Ralph Weissleder Nature Biotechnology 23, 313 - 320 (2005
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:72170
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:18 Nov 2016 22:17
Last Modified:11 Nov 2021 04:57

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