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Redox Signaling through DNA

O'Brien, Elizabeth and Silva, Rebekah M. B. and Barton, Jacqueline K. (2016) Redox Signaling through DNA. Israel Journal of Chemistry, 56 (9-10). pp. 705-723. ISSN 0021-2148. PMCID PMC5225960. doi:10.1002/ijch.201600022. https://resolver.caltech.edu/CaltechAUTHORS:20161128-100708366

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Abstract

Biological electron transfer reactions between metal cofactors are critical to many essential processes within the cell. Duplex DNA is, moreover, capable of mediating the transport of charge through its π-stacked nitrogenous bases. Increasingly, [4Fe4S] clusters, generally redox-active cofactors, have been found to be associated with enzymes involved in DNA processing. DNA-binding enzymes containing [4Fe4S] clusters can thus utilize DNA charge transport (DNA CT) for redox signaling to coordinate reactions over long molecular distances. In particular, DNA CT signaling may represent the first step in the search for DNA lesions by proteins containing [4Fe4S] clusters that are involved in DNA repair. Here we describe research carried out to examine the chemical characteristics and biological consequences of DNA CT. We are finding that DNA CT among metalloproteins represents powerful chemistry for redox signaling at long range within the cell.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1002/ijch.201600022 DOIArticle
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5225960PubMed CentralArticle
ORCID:
AuthorORCID
Barton, Jacqueline K.0000-0001-9883-1600
Additional Information:© 2016 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim. Issue online: 4 October 2016; Version of record online: 29 July 2016; Manuscript Received: 1 April 2016. We are grateful to our many coworkers and collaborators for their contributions to this research. We are also especially grateful to our colleague, Harry Gray, for many insights, both respect to protein electron transfer and beyond! E.O.B. thanks the NIH for training and R.M.B.S. thanks the NSF for fellowship support. We are also grateful to the NIH (GM61077) and the Moore foundation for their financial support.
Funders:
Funding AgencyGrant Number
NIHGM61077
NSFUNSPECIFIED
Gordon and Betty Moore FoundationUNSPECIFIED
Subject Keywords:bioinorganic chemistry; DNA; electron transport; metalloproteins; redox chemistry
Issue or Number:9-10
PubMed Central ID:PMC5225960
DOI:10.1002/ijch.201600022
Record Number:CaltechAUTHORS:20161128-100708366
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20161128-100708366
Official Citation:E. O'Brien, R. M. B. Silva, J. K. Barton, Isr. J. Chem. 2016, 56, 705
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:72302
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:28 Nov 2016 18:22
Last Modified:11 Nov 2021 04:59

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