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Evidence for a tryptophane cycle in Neurospora

Haskins, Francis A. and Mitchell, Herschel K. (1949) Evidence for a tryptophane cycle in Neurospora. Proceedings of the National Academy of Sciences of the United States of America, 35 (9). pp. 500-506. ISSN 0027-8424. doi:10.1073/pnas.35.9.500.

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The work of Snell(1) on lactic acid bacteria provided the first evidence that anthranilic acid may act as a precursor to tryptophane in vivo. Since the strains of bacteria which utilize anthranilic acid in the place of tryptophane also use indole, it was not possible to establish the order in which these two precursors occurred. In 1943 Tatum, Bonner and Beadle(2) found that anthranilic acid was accumulated in the culture medium by a Neurospora crassa mutant, strain 10575, which required either tryptophane or indole for growth. It was therefore indicated that anthranilic acid is a precursor to indole in Neurospora.

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Additional Information:© 1949 by the National Academy of Sciences. Communicated by G. W. Beadle, July 15, 1949. This work was supported by funds from the Rockefeller Foundation and by funds from the Atomic Energy Commission administered through contract with the Office of Naval Research, United States Navy, Contract N6 onr-244 Task order V.
Issue or Number:9
Record Number:CaltechAUTHORS:HASpnas49
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:7242
Deposited By: Tony Diaz
Deposited On:23 Jan 2007
Last Modified:08 Nov 2021 20:40

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