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Mapping the microscale origins of magnetic resonance image contrast with subcellular diamond magnetometry

Davis, Hunter C. and Ramesh, Pradeep and Bhatnagar, Aadyot and Lee-Gosselin, Audrey and Barry, John F. and Glenn, David R. and Walsworth, Ronald L. and Shapiro, Mikhail G. (2018) Mapping the microscale origins of magnetic resonance image contrast with subcellular diamond magnetometry. Nature Communications, 9 . Art. No. 131. ISSN 2041-1723. PMCID PMC5760582. http://resolver.caltech.edu/CaltechAUTHORS:20161205-095517669

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Abstract

Magnetic resonance imaging (MRI) is a widely used biomedical imaging modality that derives much of its contrast from microscale magnetic field gradients in biological tissues. However, the connection between these sub-voxel field patterns and MRI contrast has not been studied experimentally. Here, we describe a new method to map subcellular magnetic fields in mammalian cells and tissues using nitrogen vacancy diamond magnetometry and connect these maps to voxel-scale MRI contrast, providing insights for in vivo imaging and contrast agent design.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://dx.doi.org/10.1038/s41467-017-02471-7DOIArticle
https://www.nature.com/articles/s41467-017-02471-7PublisherArticle
https://arxiv.org/abs/1610.01924arXivDiscussion Paper
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5760582PubMed CentralArticle
ORCID:
AuthorORCID
Davis, Hunter C.0000-0003-1655-692X
Shapiro, Mikhail G.0000-0002-0291-4215
Alternate Title:Mapping the Microscale Origins of MRI Contrast with Subcellular NV Diamond Magnetometry
Additional Information:© 2018 The Authors. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. Received: 15 April 2017. Accepted: 03 December 2017. Published online: 09 January 2018. We acknowledge Arnab Mukherjee, George Lu, Vivek Bharadwaj, My Linh Pham, Andrei Faraon, Geoffrey Blake, Joe Kirschvink, Manuel Monge, Hans Gruber, Michael Tyszka, Russ Jacobs, and John Wood for helpful discussions. This work was supported by the National Science Foundation Graduate Research Fellowship (P.R.), Caltech Center for Environmental–Microbial Interactions (M.G.S.), the Burroughs Wellcome Fund (M.G.S.), the NSF EPMD and PoLS programs (R.L.W.), and the U. S. Army Research Laboratory and the U. S. Army Research Office under contract/grant number W911NF1510548 (R.L.W.). Research in the Shapiro Laboratory is also supported by the Heritage Medical Research Institute, the Pew Scholarship in the Biomedical Sciences and the David and Lucile Packard Fellowship for Science and Engineering. Hunter C. Davis and Pradeep Ramesh contributed equally to this work. Author Contributions: H.C.D., P.R. and M.G.S. conceived and planned the study with input from J.F.B., D.R.G. and R.L.W. H.C.D., P.R. and J.F.B. constructed the magneto-microscope. H.C.D. performed the NV magnetometry experiments and analyzed the resulting data. H.C.D., P.R. and A.L.-G. prepared the in vitro and in vivo specimens. P.R. and H.C.D. performed the MRI measurements and analyzed the resulting data. H.C.D. and A.B. developed and performed the Monte Carlo simulations. H.C.D., P.R. and M.G.S. wrote the manuscript with input from all other authors. Code availability: All the relevant software scripts are available from the authors upon request. Data availability: All the relevant data are available from the authors upon request. The authors declare no competing financial interests.
Group:Heritage Medical Research Institute, Caltech Center for Environmental Microbial Interactions (CEMI)
Funders:
Funding AgencyGrant Number
NSF Graduate Research FellowshipUNSPECIFIED
Caltech Center for Environmental Microbial Interactions (CEMI)UNSPECIFIED
Burroughs Wellcome FundUNSPECIFIED
NSFUNSPECIFIED
Army Research Office (ARO)UNSPECIFIED
Heritage Medical Research InstituteUNSPECIFIED
PubMed Central ID:PMC5760582
Record Number:CaltechAUTHORS:20161205-095517669
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:20161205-095517669
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:72547
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:06 Dec 2016 20:48
Last Modified:17 Jan 2018 17:38

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