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Histone, a suppressor of chromosomal RNA synthesis

Huang, Ru-Chih C. and Bonner, James (1962) Histone, a suppressor of chromosomal RNA synthesis. Proceedings of the National Academy of Sciences of the United States of America, 48 (7). pp. 1216-1222. ISSN 0027-8424. doi:10.1073/pnas.48.7.1216.

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We have previously reported(1,2) that chromatin isolated from pea embryos possesses the ability to carry out the DNA-dependent synthesis of RNA from the four riboside triphosphates.(3) The present paper concerns the roles in such synthesis of the several components of chromatin. It will be shown that the DNA of pea embryo chromatin is present in at least two forms, namely, as DNA itself and as DNA bound in nucleohistone complex. It will be further shown that DNA fully complexed with histone is inactive in the support of DNA-dependent RNA synthesis.

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Additional Information:© 1962 by the National Academy of Sciences. Communicated May 22, 1962. Report of work supported by the U.S. Public Health Service, grants no. RG-3977, RG-5143, and A-3102. We wish to acknowledge the fine technical assistance of Hedi Imfeld and the counsel and cooperation of F. William Studier.
Issue or Number:7
Record Number:CaltechAUTHORS:HUApnas62
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:7264
Deposited By: Tony Diaz
Deposited On:25 Jan 2007
Last Modified:08 Nov 2021 20:40

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