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Photoacoustic Tomography of a Nanoshell Contrast Agent in the in Vivo Rat Brain

Wang, Yiwen and Xie, Xueyi and Wang, Xueding and Ku, Geng and Gill, Kelly L. and O'Neal, D. Patrick and Stoica, George and Wang, Lihong V. (2004) Photoacoustic Tomography of a Nanoshell Contrast Agent in the in Vivo Rat Brain. Nano Letters, 4 (9). pp. 1689-1692. ISSN 1530-6984. http://resolver.caltech.edu/CaltechAUTHORS:20161207-155728543

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Abstract

This study demonstrates the feasibility of using nanoshells in vivo as a new contrast-enhancing agent for photoacoustic tomography. Deep penetrating near-infrared light was employed to image the in vivo distribution of poly(ethylene glycol)-coated nanoshells circulating in the vasculature of a rat brain. The images, captured after three sequential administrations of nanoshells, present a gradual enhancement of the optical absorption in the brain vessels by up to 63%. Subsequent clearance of the nanoshells from the blood was imaged for ∼6 h after the administrations.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1021/nl049126aDOIArticle
http://pubs.acs.org/doi/abs/10.1021/nl049126aPublisherArticle
ORCID:
AuthorORCID
Wang, Lihong V.0000-0001-9783-4383
Additional Information:© 2004 American Chemical Society. Received June 8, 2004. Publication Date (Web): August 10, 2004.
Record Number:CaltechAUTHORS:20161207-155728543
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:20161207-155728543
Official Citation:Photoacoustic Tomography of a Nanoshell Contrast Agent in the in Vivo Rat Brain Yiwen Wang, Xueyi Xie, Xueding Wang, Geng Ku, Kelly L. Gill, D. Patrick O'Neal, George Stoica, and, and Lihong V. Wang, Nano Letters 2004 4 (9), 1689-1692 DOI: 10.1021/nl049126a
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:72641
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:08 Dec 2016 00:09
Last Modified:08 Dec 2016 00:09

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