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MEMS oxygen transport device for islet transplantation in the subcutaneous site

Kang, Dongyang and Komatsu, Hirotake and Lin, Henry and Cook, Colin A. and Tai, Yu-Chong and Mullen, Yoko and Kandeel, Fouad R. (2016) MEMS oxygen transport device for islet transplantation in the subcutaneous site. In: Proceedings of the 11th IEEE Annual International Conference on Nano/Micro Engineered and Molecular Systems (NEMS). IEEE , Piscataway, NJ. ISBN 978-1-5090-1947-2. http://resolver.caltech.edu/CaltechAUTHORS:20161209-093102216

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Abstract

This paper presents a new MEMS approach of maintaining islet oxygenation for subcutaneous islet transplantation therapy of type 1 diabetes by engineering a MEMS oxygen transport device. A device is designed and fabricated. Bench-top testing and computational modeling of the device have demonstrated that it would provide sufficient oxygen to prevent hypoxia-induced islet death and maintain the functional metabolic activity of glucose-simulated insulin secretion for islets transplanted subcutaneously.


Item Type:Book Section
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1109/NEMS.2016.7758299 DOIArticle
http://ieeexplore.ieee.org/document/7758299/PublisherArticle
http://dx.doi.org/10.1049/mnl.2016.0303Related ItemJournal Article
ORCID:
AuthorORCID
Tai, Yu-Chong0000-0001-8529-106X
Additional Information:© 2016 IEEE. This work is financially supported by City of Hope. The authors gratefully acknowledge the help of all the members from the Caltech Micromachining Lab and City of Hope’s Diabetes and Metabolic Researches Department.
Funders:
Funding AgencyGrant Number
City of HopeUNSPECIFIED
Subject Keywords:type 1 diabetes; islet transplantation; hypoxia; MEMS oxygen transport device
Record Number:CaltechAUTHORS:20161209-093102216
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:20161209-093102216
Official Citation:D. Kang et al., "MEMS oxygen transport device for islet transplantation in the subcutaneous site," 2016 IEEE 11th Annual International Conference on Nano/Micro Engineered and Molecular Systems (NEMS), Sendai, Japan, 2016, pp. 499-503. doi: 10.1109/NEMS.2016.7758299
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:72688
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:09 Dec 2016 19:45
Last Modified:09 Dec 2016 19:45

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