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Adjacent chromosomal regions can evolve at very different rates: Evolution of the Drosophila 68C glue gene cluster

Meyerowitz, Elliot M. and Martin, Christopher H. (1984) Adjacent chromosomal regions can evolve at very different rates: Evolution of the Drosophila 68C glue gene cluster. Journal of Molecular Evolution, 20 (3-4). pp. 251-264. ISSN 0022-2844. https://resolver.caltech.edu/CaltechAUTHORS:20161212-092413157

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Abstract

The 68C puff is a highly transcribed region of theDrosophila melanogaster salivary gland polytene chromosomes. Three different classes of messenger RNA originate in a 5000-bp region in the puff; each class is translated to one of the salivary gland glue proteins sgs-3, sgs-7, or sgs-8. These messenger RNA classes are coordinately controlled, with each RNA appearing in the third larval instar and disappearing at the time of puparium formation. Their disappearance is initiated by the action of the steroid hormone ecdysterone. In the work reported here, we studied evolution of this hormone-regulated gene cluster in themelanogaster species subgroup ofDrosophila. Genome blot hybridization experiments showed that five other species of this subgroup have DNA sequences that hybridize toD. melanogaster 68C sequences, and that these sequences are divided into a highly conserved region, which does not contain the glue genes, and an extraordinarily diverged region, which does. Molecular cloning of this DNA fromD. simulans, D. erecta, D. yakuba, andD. teissieri confirmed the division of the region into a slowly and a rapidly evolving protion, and also showed that the rapidly evolving region of each species codes for third instar larval salivary gland RNAs homologous to theD. melanogaster glue mRNAs. The highly conserved region is at least 13,000 bp long, and is not known to code for any RNAs.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1007/BF02104731DOIArticle
http://link.springer.com/article/10.1007%2FBF02104731PublisherArticle
ORCID:
AuthorORCID
Meyerowitz, Elliot M.0000-0003-4798-5153
Additional Information:© 1984 Springer-Verlag New York Inc.
Subject Keywords:Drosophila; Genome evolution; 68C Glue gene cluster; Drosophila melanogaster species subgroup
Issue or Number:3-4
Record Number:CaltechAUTHORS:20161212-092413157
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20161212-092413157
Official Citation:Meyerowitz, E.M. & Martin, C.H. J Mol Evol (1984) 20: 251. doi:10.1007/BF02104731
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:72705
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:12 Dec 2016 18:15
Last Modified:03 Oct 2019 16:20

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