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Th2 Cells in Health and Disease

Nakayama, Toshinori and Hirahara, Kiyoshi and Onodera, Atsushi and Endo, Yusuke and Hosokawa, Hiroyuki and Shinoda, Kenta and Tumes, Damon J. and Okamoto, Yoshitaka (2017) Th2 Cells in Health and Disease. Annual Review of Immunology, 35 . pp. 53-84. ISSN 0732-0582. https://resolver.caltech.edu/CaltechAUTHORS:20161212-094455121

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Abstract

Helper T (Th) cell subsets direct immune responses by producing signature cytokines. Th2 cells produce IL-4, IL-5, and IL-13, which are important in humoral immunity and protection from helminth infection and are central to the pathogenesis of many allergic inflammatory diseases. Molecular analysis of Th2 cell differentiation and maintenance of function has led to recent discoveries that have refined our understanding of Th2 cell biology. Epigenetic regulation of Gata3 expression by chromatin remodeling complexes such as Polycomb and Trithorax is crucial for maintaining Th2 cell identity. In the context of allergic diseases, memory-type pathogenic Th2 cells have been identified in both mice and humans. To better understand these disease-driving cell populations, we have developed a model called the pathogenic Th population disease induction model. The concept of defined subsets of pathogenic Th cells may spur new, effective strategies for treating intractable chronic inflammatory disorders.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1146/annurev-immunol-051116-052350DOIArticle
ORCID:
AuthorORCID
Hosokawa, Hiroyuki0000-0002-9592-2889
Additional Information:© 2016 Annual Reviews. Review in Advance first posted online on November 28, 2016. We are grateful for Drs. Omid Akbari, Mark Bix, Steven Ziegler, and Magdalene Papadopoulos, for their critical reading and providing valuable suggestions on the manuscript. We apologize to colleagues whose excellent work we were unable to include because of space limitations. The authors are not aware of any affiliations, memberships, funding, or financial holdings that might be perceived as affecting the objectivity of this review.
Subject Keywords:Th2, allergy, epigenetics, Polycomb, Trithorax, Gata3, pathogenic Th2 cell
Record Number:CaltechAUTHORS:20161212-094455121
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20161212-094455121
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:72710
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:12 Dec 2016 18:24
Last Modified:29 Oct 2019 23:00

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