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Ethylene Responses Are Negatively Regulated by a Receptor Gene Family in Arabidopsis thaliana

Hua, Jian and Meyerowitz, Elliot M. (1998) Ethylene Responses Are Negatively Regulated by a Receptor Gene Family in Arabidopsis thaliana. Cell, 94 (2). pp. 261-271. ISSN 0092-8674. doi:10.1016/S0092-8674(00)81425-7.

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A family of genes including ETR1, ETR2, EIN4, ERS1, and ERS2 is implicated in ethylene perception in Arabidopsis thaliana. As only dominant mutations were previously available for these genes, it was unclear whether all of them are components in the ethylene signaling pathway and whether they code for positive or negative regulators of ethylene responses. In this study, we have isolated loss-of-function mutations of four of these genes (ETR1, ETR2, EIN4, and ERS2) and identified an ethylene-independent role of ETR1 in promoting cell elongation. Quadruple mutants had constitutive ethylene responses, revealing that these proteins negatively regulate ethylene responses and that the induction of ethylene response in Arabidopsis is through inactivation rather than activation of these proteins.

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Meyerowitz, Elliot M.0000-0003-4798-5153
Additional Information:© 1998 Cell Press. Received May 18, 1998; revised June 22, 1998. We are grateful to Dr. H. Kende for allowing J. H. to do the dose–response experiments in his laboratory, and to Dr. S. C. Peck for teaching her how to do it. We thank A. Wang for technical assistance. We also thank C. Chang, X. Chen, J. Fletcher, T. Ito, P. Kumar, C. Ohno, K. Roberg, R. Sablowski, G. E. Schaller, D. Wagner, and E. Ziegelhoffer for critical reading of this manuscript. etr2-1 and ein4-1 seeds were kindly provided by Dr. A. B. Bleecker and Dr. J. R. Ecker, respectively. The DNA pools of the T-DNA lines were obtained from the Arabidopsis Biological Resource Center. This research was supported by DOE grant FG03-88ER13873 to E. M. M.
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Department of Energy (DOE)DE-FG03-88ER13873
Issue or Number:2
Record Number:CaltechAUTHORS:20161214-144139057
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Official Citation:Jian Hua, Elliot M Meyerowitz, Ethylene Responses Are Negatively Regulated by a Receptor Gene Family in Arabidopsis thaliana, Cell, Volume 94, Issue 2, 24 July 1998, Pages 261-271, ISSN 0092-8674, (
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:72828
Deposited By: George Porter
Deposited On:15 Dec 2016 16:34
Last Modified:11 Nov 2021 05:07

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