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Negative regulation of the Arabidopsis homeotic gene AGAMOUS by the APETALA2 product

Drews, Gary N. and Bowman, John L. and Meyerowitz, Elliot M. (1991) Negative regulation of the Arabidopsis homeotic gene AGAMOUS by the APETALA2 product. Cell, 65 (6). pp. 991-1002. ISSN 0092-8674. doi:10.1016/0092-8674(91)90551-9.

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We characterized the distribution of AGAMOUS (AG) RNA during early flower development in Arabidopsis. Mutations in this homeotic gene cause the transformation of stamens to petals in floral whorl 3 and of carpels to another ag flower in floral whorl 4. We found that AG RNA is present in the stamen and carpel primordia but is undetectable in sepal and petal primordia throughout early wild-type flower development, consistent with the mutant phenotype. We also analyzed the distribution of AG RNA in apetela2 (ap2) mutant flowers. AP2 is a floral homeotic gene that is necessary for the normal development of sepals and petals in floral whorls 1 and 2. In ap2 mutant flowers, AG RNA is present in the organ primordia of all floral whorls. These observations show that the expression patterns of the Arabidopsis floral homeotic genes are in part established by regulatory interactions between these genes.

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Meyerowitz, Elliot M.0000-0003-4798-5153
Additional Information:© 1991 Cell Press. Received 7 February 1991, Revised 3 April 1991. We thank the other members of our laboratory and David Smyth for providing materials and advice and for comments on the manuscript. This work is supported by National Science Foundation grant DCB-8703439 to E.M.M. G.N.D. is supported by NIH postdoctoral fellowship GM13100-03, and J.L.B. is partially supported by NIH training grant 5T32-GM07616. The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked “advertisement” in accordance with 18 USC Section 1734 solely to indicate this fact.
Funding AgencyGrant Number
NIH Postdoctoral FellowshipGM13100-03
NIH Predoctoral Fellowship5T32-GM07616
Issue or Number:6
Record Number:CaltechAUTHORS:20161214-145325112
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Official Citation:Gary N. Drews, John L. Bowman, Elliot M. Meyerowitz, Negative regulation of the Arabidopsis homeotic gene AGAMOUS by the APETALA2 product, Cell, Volume 65, Issue 6, 1991, Pages 991-1002, ISSN 0092-8674, (
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:72829
Deposited By: George Porter
Deposited On:15 Dec 2016 15:51
Last Modified:11 Nov 2021 05:07

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