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The CLAVATA1 Gene Encodes a Putative Receptor Kinase That Controls Shoot and Floral Meristem Size in Arabidopsis

Clark, Steven E. and Williams, Robert W. and Meyerowitz, Elliot M. (1997) The CLAVATA1 Gene Encodes a Putative Receptor Kinase That Controls Shoot and Floral Meristem Size in Arabidopsis. Cell, 89 (4). pp. 575-585. ISSN 0092-8674. https://resolver.caltech.edu/CaltechAUTHORS:20161214-155104303

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Abstract

The shoot apical meristem is responsible for above-ground organ initiation in higher plants, accomplishing continuous organogenesis by maintaining a pool of undifferentiated cells and directing descendant cells toward organ formation. Normally, proliferation and differentiation are balanced, so that the structure and size of the shoot meristem is maintained. However, Arabidopsis plants homozygous for mutations at the CLAVATA1 (CLV1) locus accumulate excess undifferentiated cells. We describe the molecular cloning and expression pattern of the CLV1 gene. It encodes a putative receptor kinase, suggesting a role in signal transduction. The extracellular domain is composed of 21 tandem leucine-rich repeats that resemble leucine-rich repeats found in animal hormone receptors. We provide evidence that CLV1 expression in the inflorescence is specifically associated with meristematic activity.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1016/S0092-8674(00)80239-1DOIArticle
http://www.sciencedirect.com/science/article/pii/S0092867400802391PublisherArticle
ORCID:
AuthorORCID
Meyerowitz, Elliot M.0000-0003-4798-5153
Additional Information:© 1997 Cell Press. Received 27 February 1997, Revised 11 April 1997. The authors would like to thank Hajime Sakai and Leonard Medrano for invaluable technical assistance and advice. We also thank Ephraim Simon for sectioning material for in situ hybridization, Amy Trotochaud for technical assistance in generating transgenic plants, and Michael Frohlich for assistance with the phylogenetic analysis. We are grateful to Steve Jacobsen for isolating the clv1–9 allele and June Medford for providing the clv1–8 allele. We also thank X. Chen, J. Fletcher, J. Hua, J.-L. Riechmann, M. Running, R. Sablowski, H. Sakai, D. Wagner, and E. Zeigelhoffer for careful review of this manuscript. ga2 seeds were provided by the Arabidopsis Biological Resource Center at Ohio State University. This work was supported by NSF grant MCB-9204839 and a Strategic Research Fund Grant from Zeneca Seeds to E. M. M., and an NSF Developmental Mechanisms grant to S. E. C. (IBN 9506952). S. E. C. was an NSF Plant Biology Postdoctoral Fellow, and R. W. W. was supported by NIH Predoctoral Training Grant GM07616 and the Howard Hughes Medical Institute. The GenBank accession numbers for the sequences reported in this article are U96879 for CLV1 and U96877 and U96878 for AtVPS-35.
Funders:
Funding AgencyGrant Number
NSFMCB-9204839
Zeneca SeedsUNSPECIFIED
NSFIBN-9506952
NSF Plant Biology Postdoctoral FellowshipUNSPECIFIED
NIH Predoctoral FellowshipGM07616
Howard Hughes Medical Institute (HHMI)UNSPECIFIED
Issue or Number:4
Record Number:CaltechAUTHORS:20161214-155104303
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20161214-155104303
Official Citation:Steven E Clark, Robert W Williams, Elliot M Meyerowitz, The CLAVATA1 Gene Encodes a Putative Receptor Kinase That Controls Shoot and Floral Meristem Size in Arabidopsis, Cell, Volume 89, Issue 4, 16 May 1997, Pages 575-585, ISSN 0092-8674, http://dx.doi.org/10.1016/S0092-8674(00)80239-1. (http://www.sciencedirect.com/science/article/pii/S0092867400802391)
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:72836
Collection:CaltechAUTHORS
Deposited By: George Porter
Deposited On:15 Dec 2016 18:06
Last Modified:03 Oct 2019 16:21

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