Kazemi-Esfarjani, Parsa and Benzer, Seymour (2002) Suppression of polyglutamine toxicity by a Drosophila homolog of myeloid leukemia factor 1. Human Molecular Genetics, 11 (21). pp. 2657-2672. ISSN 0964-6906. doi:10.1093/hmg/11.21.2657. https://resolver.caltech.edu/CaltechAUTHORS:KAZhmg02
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Abstract
The toxicity of an abnormally long polyglutamine [poly(Q)] tract within specific proteins is the molecular lesion shared by Huntington's disease (HD) and several other hereditary neurodegenerative disorders. By a genetic screen in Drosophila, devised to uncover genes that suppress poly(Q) toxicity, we discovered a Drosophila homolog of human myeloid leukemia factor 1 (MLF1). Expression of the Drosophila homolog (dMLF) ameliorates the toxicity of poly(Q) expressed in the eye and central nervous system. In the retina, whether endogenously or ectopically expressed, dMLF co-localized with aggregates, suggesting that dMLF alone, or through an intermediary molecular partner, may suppress toxicity by sequestering poly(Q) and/or its aggregates.
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| Additional Information: | © 2002 Oxford University Press. Received July 22, 2002; accepted July 31, 2002. We thank Dr Chris Q. Doe for the gift of prospero cDNA clone p139cAC1, Dr Kalpana White for Appl-GAL4 driver lines and anti-ELAV 7D4E6 monoclonal antibody, Drs Masamitsu Yamaguchi and Fumiko Hirose for anti-dMLF monoclonal antibody, UAS-dref, UAS-dref CR1 and UAS-zen, Dr Sarah Smolik for chicken anti-dCBP polyclonal antibody, Dr George Jackson for HttQ120 transgenic mutant HD fly line, Dr Laurent Seroude for the transgenic vector pINDY6, and Viveca Sapin, Rosalind Young, Amparo Gomez and Ekaterina Passetchnik for invaluable technical support. P.K.-E. was supported by fellowships from Cure HD Initiative/Hereditary Disease Foundation, and grants from The Wills Foundation, NINDS/NIH (NS42162), and Howard Hughes Medical Institute Biomedical Research Support Program (53000261), and grants to S.B. from the NSF, the NIH and the James G. Boswell Foundation. DDBJ/EMBL/GenBank accession no. AY037049 | ||||||||||||||||
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| Issue or Number: | 21 | ||||||||||||||||
| DOI: | 10.1093/hmg/11.21.2657 | ||||||||||||||||
| Record Number: | CaltechAUTHORS:KAZhmg02 | ||||||||||||||||
| Persistent URL: | https://resolver.caltech.edu/CaltechAUTHORS:KAZhmg02 | ||||||||||||||||
| Official Citation: | Parsa Kazemi-Esfarjani, Seymour Benzer; Suppression of polyglutamine toxicity by a Drosophila homolog of myeloid leukemia factor 1, Human Molecular Genetics, Volume 11, Issue 21, 2 October 2002, Pages 2657–2672, https://doi.org/10.1093/hmg/11.21.2657 | ||||||||||||||||
| Usage Policy: | No commercial reproduction, distribution, display or performance rights in this work are provided. | ||||||||||||||||
| ID Code: | 7286 | ||||||||||||||||
| Collection: | CaltechAUTHORS | ||||||||||||||||
| Deposited By: | Lindsay Cleary | ||||||||||||||||
| Deposited On: | 26 Jan 2007 | ||||||||||||||||
| Last Modified: | 08 Nov 2021 20:41 |
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