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Suppression of polyglutamine toxicity by a Drosophila homolog of myeloid leukemia factor 1

Kazemi-Esfarjani, Parsa and Benzer, Seymour (2002) Suppression of polyglutamine toxicity by a Drosophila homolog of myeloid leukemia factor 1. Human Molecular Genetics, 11 (21). pp. 2657-2672. ISSN 0964-6906. doi:10.1093/hmg/11.21.2657. https://resolver.caltech.edu/CaltechAUTHORS:KAZhmg02

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Abstract

The toxicity of an abnormally long polyglutamine [poly(Q)] tract within specific proteins is the molecular lesion shared by Huntington's disease (HD) and several other hereditary neurodegenerative disorders. By a genetic screen in Drosophila, devised to uncover genes that suppress poly(Q) toxicity, we discovered a Drosophila homolog of human myeloid leukemia factor 1 (MLF1). Expression of the Drosophila homolog (dMLF) ameliorates the toxicity of poly(Q) expressed in the eye and central nervous system. In the retina, whether endogenously or ectopically expressed, dMLF co-localized with aggregates, suggesting that dMLF alone, or through an intermediary molecular partner, may suppress toxicity by sequestering poly(Q) and/or its aggregates.


Item Type:Article
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https://doi.org/10.1093/hmg/11.21.2657DOIArticle
http://hmg.oxfordjournals.org/cgi/content/abstract/11/21/2657OtherUNSPECIFIED
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Additional Information:© 2002 Oxford University Press. Received July 22, 2002; accepted July 31, 2002. We thank Dr Chris Q. Doe for the gift of prospero cDNA clone p139cAC1, Dr Kalpana White for Appl-GAL4 driver lines and anti-ELAV 7D4E6 monoclonal antibody, Drs Masamitsu Yamaguchi and Fumiko Hirose for anti-dMLF monoclonal antibody, UAS-dref, UAS-dref CR1 and UAS-zen, Dr Sarah Smolik for chicken anti-dCBP polyclonal antibody, Dr George Jackson for HttQ120 transgenic mutant HD fly line, Dr Laurent Seroude for the transgenic vector pINDY6, and Viveca Sapin, Rosalind Young, Amparo Gomez and Ekaterina Passetchnik for invaluable technical support. P.K.-E. was supported by fellowships from Cure HD Initiative/Hereditary Disease Foundation, and grants from The Wills Foundation, NINDS/NIH (NS42162), and Howard Hughes Medical Institute Biomedical Research Support Program (53000261), and grants to S.B. from the NSF, the NIH and the James G. Boswell Foundation. DDBJ/EMBL/GenBank accession no. AY037049
Funders:
Funding AgencyGrant Number
Hereditary Disease FoundationUNSPECIFIED
Wills FoundationUNSPECIFIED
NIHNS42162
Howard Hughes Medical Institute (HHMI)53000261
NSFUNSPECIFIED
James G. Boswell FoundationUNSPECIFIED
National Institute of Neurological Disorders and Stroke (NINDS)UNSPECIFIED
Issue or Number:21
DOI:10.1093/hmg/11.21.2657
Record Number:CaltechAUTHORS:KAZhmg02
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:KAZhmg02
Official Citation:Parsa Kazemi-Esfarjani, Seymour Benzer; Suppression of polyglutamine toxicity by a Drosophila homolog of myeloid leukemia factor 1, Human Molecular Genetics, Volume 11, Issue 21, 2 October 2002, Pages 2657–2672, https://doi.org/10.1093/hmg/11.21.2657
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:7286
Collection:CaltechAUTHORS
Deposited By: Lindsay Cleary
Deposited On:26 Jan 2007
Last Modified:08 Nov 2021 20:41

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