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Environmental exposure to DDT and its metabolites in cord serum: Distribution, enantiomeric patterns, and effects on infant birth outcomes

Xu, Chenye and Yin, Shanshan and Tang, Mengling and Liu, Kai and Yang, Fangxin and Liu, Weiping (2017) Environmental exposure to DDT and its metabolites in cord serum: Distribution, enantiomeric patterns, and effects on infant birth outcomes. Science of the Total Environment, 580 . pp. 491-498. ISSN 0048-9697. https://resolver.caltech.edu/CaltechAUTHORS:20170103-131844353

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Abstract

Previous in vivo studies have suggested that prenatal exposure to dichlorodiphenyltrichloroethane (DDT) is endocrine disrupting, and may cause adverse health risks to newborns. In this cross-sectional study, non-invasive cord serum samples were collected from maternal-neonate pairs of an island population. Concentrations of DDT and its metabolites were analyzed to provide insights into the environmental exposure patterns and to elucidate their effects on birth outcomes. The average concentrations of p,p’-DDE, o,p’-DDD, p,p’-DDD, o,p’-DDT, p,p’-DDT and total DDTs were 0.463, 0.293, 0.089, 0.098, 0.441 and 1.384 μg g^(− 1) lipid weight, respectively. Several maternal characteristics were identified as influencing factors on the environmental exposure distribution. The isomer ratios of individual components and the enantiomeric patterns of o,p’-DDD and o,p’-DDT indicated that historical technical DDT remains the predominant exposure source, though new sources of dicofol-type of DDT pollution must not be ignored. Using multivariable linear regression, increasing p,p’-DDD and p,p’-DDT levels were found to be significantly associated with an increase in neonatal birth weight, which deserves additional attention to obesity risks. No other birth outcome was found to be significant regarding DDT exposure. These findings raise the awareness of the prenatal risk of DDT and its metabolites among infants in contaminated areas.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1016/j.scitotenv.2016.11.196DOIArticle
http://www.sciencedirect.com/science/article/pii/S0048969716326626PublisherArticle
ORCID:
AuthorORCID
Yin, Shanshan0000-0001-8859-9852
Tang, Mengling0000-0003-2876-9199
Liu, Kai0000-0002-2109-8196
Liu, Weiping0000-0002-1173-892X
Additional Information:© 2016 Elsevier B.V. Received 25 October 2016, Revised 27 November 2016, Accepted 27 November 2016, Available online 15 December 2016.
Subject Keywords:DDT; Environmental exposure; Cord serum; Enantiomeric patterns; Birth outcomes
Record Number:CaltechAUTHORS:20170103-131844353
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20170103-131844353
Official Citation:Chenye Xu, Shanshan Yin, Mengling Tang, Kai Liu, Fangxin Yang, Weiping Liu, Environmental exposure to DDT and its metabolites in cord serum: Distribution, enantiomeric patterns, and effects on infant birth outcomes, Science of The Total Environment, Volume 580, 15 February 2017, Pages 491-498, ISSN 0048-9697, http://doi.org/10.1016/j.scitotenv.2016.11.196. (http://www.sciencedirect.com/science/article/pii/S0048969716326626)
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:73179
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:03 Jan 2017 21:29
Last Modified:11 Oct 2019 20:08

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