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Non-coding RNAs in Transcriptional Regulation

Chen, Yung-Chia Ariel and Aravin, Alexei A. (2015) Non-coding RNAs in Transcriptional Regulation. Current Molecular Biology Reports, 1 (1). pp. 10-18. ISSN 2198-6428. PMCID PMC4479201.

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Transcriptional gene silencing guided by small RNAs is a process conserved from protozoa to mammals. Small RNAs loaded into Argonaute family proteins direct repressive histone modifications or DNA cytosine methylation to homologous regions of the genome. Small RNA-mediated transcriptional silencing is required for many biological processes, including repression of transposable elements, maintaining the genome stability/integrity, and epigenetic inheritance of gene expression. Here, we will summarize the current knowledge about small RNA biogenesis and mechanisms of transcriptional regulation in plants, Drosophila, Caenorhabditis elegans, and mice. Furthermore, a rapidly growing number of long non-coding RNAs (lncRNAs) have been implicated as important players in transcription regulation. We will discuss current models for long non-coding RNA-mediated gene regulation.

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Additional Information:© 2015 Springer International Publishing AG. Published online: 17 February 2015. We thank members of the Aravin lab and particularly Alexandre Webster for discussion and comments. The work in Aravin laboratory is supported by grants from the National Institutes of Health (R01 GM097363 and DP2 OD007371A) and by the Damon Runyon-Rachleff, the Searle Scholar, and the Packard Fellowship Awards to A.A.A. Compliance with Ethics Guidelines. Yung-Chia Ariel Chen and Alexei A. Aravin declare that they have no conflict of interest. Human and Animal Rights and Informed Consent: This article does not contain any studies with human or animal subjects performed by any of the authors.
Funding AgencyGrant Number
NIHR01 GM097363
NIHDP2 OD007371A
Damon Runyon Cancer Research FoundationUNSPECIFIED
Searle Scholars ProgramUNSPECIFIED
David and Lucile Packard FoundationUNSPECIFIED
Subject Keywords:Small RNA; lncRNA; Argonaute; PIWI; TGS; RdDM
Issue or Number:1
PubMed Central ID:PMC4479201
Record Number:CaltechAUTHORS:20170104-154530088
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Official Citation:Chen, YC.A. & Aravin, A.A. Curr Mol Bio Rep (2015) 1: 10. doi:10.1007/s40610-015-0002-6
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:73234
Deposited By: Tony Diaz
Deposited On:04 Jan 2017 23:54
Last Modified:03 Oct 2019 16:25

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