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Cell-selective proteomics for biological discovery

Stone, Shannon E. and Glenn, Weslee S. and Hamblin, Graham D. and Tirrell, David A. (2017) Cell-selective proteomics for biological discovery. Current Opinion in Chemical Biology, 36 . pp. 50-57. ISSN 1367-5931. PMCID PMC5337159. doi:10.1016/j.cbpa.2016.12.026.

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Cells alter the proteome to respond to environmental and developmental cues. Global analysis of proteomic responses is of limited value in heterogeneous environments, where there is no ‘average’ cell. Advances in sequencing, protein labeling, mass spectrometry, and data analysis have fueled recent progress in the investigation of specific subpopulations of cells in complex systems. Here we highlight recently developed chemical tools that enable cell-selective proteomic analysis of complex biological systems, from bacterial pathogens to whole animals.

Item Type:Article
Related URLs:
URLURL TypeDescription CentralArticle
Stone, Shannon E.0000-0002-6617-3874
Glenn, Weslee S.0000-0001-7733-7291
Tirrell, David A.0000-0003-3175-4596
Additional Information:© 2017 Elsevier B.V. Available online 12 January 2017. Caltech research on cell-specific proteomic analysis has been supported by NIH grants R01-GM062523 and R21-AI121890, and by the Institute for Collaborative Biotechnologies through grant W911NF-09-0001 from the U.S. Army Research Office.
Group:Caltech Center for Environmental Microbial Interactions (CEMI)
Funding AgencyGrant Number
Army Research Office (ARO)W911NF-09-0001
PubMed Central ID:PMC5337159
Record Number:CaltechAUTHORS:20170117-150138453
Persistent URL:
Official Citation:Shannon E Stone, Weslee S Glenn, Graham D Hamblin, David A Tirrell, Cell-selective proteomics for biological discovery, Current Opinion in Chemical Biology, Volume 36, February 2017, Pages 50-57, ISSN 1367-5931,
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:73527
Deposited By: Ruth Sustaita
Deposited On:19 Jan 2017 19:51
Last Modified:06 Apr 2022 19:28

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