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Scene-selective coding by single neurons in the human parahippocampal cortex

Mormann, Florian and Kornblith, Simon and Cerf, Moran and Ison, Matias J. and Kraskov, Alexander and Tran, Michelle and Knieling, Simeon and Quiroga, Rodrigo Quian and Koch, Christof and Fried, Itzhak (2017) Scene-selective coding by single neurons in the human parahippocampal cortex. Proceedings of the National Academy of Sciences of the United States of America, 114 (5). pp. 1153-1158. ISSN 0027-8424. PMCID PMC5293078. doi:10.1073/pnas.1608159113.

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Imaging, electrophysiological, and lesion studies have shown a relationship between the parahippocampal cortex (PHC) and the processing of spatial scenes. Our present knowledge of PHC, however, is restricted to the macroscopic properties and dynamics of bulk tissue; the behavior and selectivity of single parahippocampal neurons remains largely unknown. In this study, we analyzed responses from 630 parahippocampal neurons in 24 neurosurgical patients during visual stimulus presentation. We found a spatially clustered subpopulation of scene-selective units with an associated event-related field potential. These units form a population code that is more distributed for scenes than for other stimulus categories, and less sparse than elsewhere in the medial temporal lobe. Our electrophysiological findings provide insight into how individual units give rise to the population response observed with functional imaging in the parahippocampal place area.

Item Type:Article
Related URLs:
URLURL TypeDescription Information CentralArticle
Mormann, Florian0000-0003-1305-8028
Koch, Christof0000-0001-6482-8067
Fried, Itzhak0000-0002-5962-2678
Additional Information:© 2017 National Academy of Sciences. Freely available online through the PNAS open access option. Edited by Larry R. Squire, Veterans Affairs San Diego Healthcare System, San Diego, CA, and approved November 4, 2016 (received for review May 21, 2016). Published ahead of print January 17, 2017. We thank all our subjects for their participation; E. Behnke, T. Fields, E. Ho, V. Isiaka, E. Isham, K. Laird, N. Parikshak, and A. Postolova for technical assistance with the recordings; and D. Tsao for useful discussion. This research was supported by grants from the Volkswagen Foundation (Lichtenberg Program), the German Research Council (DFG MO930/4-1 and SFB 1089), the National Institute of Neurological Disorders and Stroke, the G. Harold and Leila Y. Mathers Foundation, the Gimbel Discovery Fund, the Dana Foundation, the Human Frontiers Science Program, and a National Science Foundation Graduate Research Fellowship (to S. Kornblith). Author contributions: F.M., S. Kornblith, C.K., and I.F. designed research; F.M., M.C., M.J.I., A.K., R.Q.Q., and I.F. performed research; F.M., M.T., and S. Knieling assessed electrode localizations; I.F. performed all neurosurgical procedures; F.M. and S. Kornblith analyzed data; and F.M., S. Kornblith, C.K., and I.F. wrote the paper. The authors declare no conflict of interest. This article is a PNAS Direct Submission. This article contains supporting information online at
Group:Koch Laboratory (KLAB)
Funding AgencyGrant Number
Volkswagen FoundationUNSPECIFIED
Deutsche Forschungsgemeinschaft (DFG)MO930/4-1
Deutsche Forschungsgemeinschaft (DFG)SFB 1089
National Institute of Neurological Disorders and Stroke (NINDS)UNSPECIFIED
G. Harold and Leila Y. Mathers FoundationUNSPECIFIED
Gimbel Discovery FundUNSPECIFIED
Dana FoundationUNSPECIFIED
Human Frontiers Science ProgramUNSPECIFIED
NSF Graduate Research FellowshipUNSPECIFIED
Subject Keywords:electrophysiology; single units; scene selectivity; population code
Issue or Number:5
PubMed Central ID:PMC5293078
Record Number:CaltechAUTHORS:20170118-082837236
Persistent URL:
Official Citation:Florian Mormann, Simon Kornblith, Moran Cerf, Matias J. Ison, Alexander Kraskov, Michelle Tran, Simeon Knieling, Rodrigo Quian Quiroga, Christof Koch, and Itzhak Fried Scene-selective coding by single neurons in the human parahippocampal cortex PNAS 2017 114 (5) 1153-1158; published ahead of print January 17, 2017, doi:10.1073/pnas.1608159113
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:73528
Deposited By: Tony Diaz
Deposited On:19 Jan 2017 18:11
Last Modified:06 Apr 2022 19:25

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