Zhang, Qiang and Lenardo, Michael J. and Baltimore, David (2017) 30 Years of NF-κB: A Blossoming of Relevance to Human Pathobiology. Cell, 168 (1-2). pp. 37-57. ISSN 0092-8674. PMCID PMC5268070. doi:10.1016/j.cell.2016.12.012. https://resolver.caltech.edu/CaltechAUTHORS:20170123-094833526
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Abstract
NF-κB was discovered 30 years ago as a rapidly inducible transcription factor. Since that time, it has been found to have a broad role in gene induction in diverse cellular responses, particularly throughout the immune system. Here, we summarize elaborate regulatory pathways involving this transcription factor and use recent discoveries in human genetic diseases to place specific proteins within their relevant medical and biological contexts.
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| Additional Information: | © 2017 Elsevier Inc. Available online 12 January 2017. We apologize to the many hundreds of colleagues over the past 30 years whose work has created this rich tapestry of science but could not be cited due to space limitations. We thank Sankar Ghosh for critically reading the manuscript. This work was supported by the Intramural Research Program of the NIAID, NIH. Author Contributions: Q.Z., M.J.L., and D.B. were involved in conceptualizing, researching, and writing this review. | |||||||||
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| Subject Keywords: | genomics; NF-κB; I-κB; human gene; Rel; immunity; lymphocyte; gene regulation; transactivator; genetic disease | |||||||||
| Issue or Number: | 1-2 | |||||||||
| PubMed Central ID: | PMC5268070 | |||||||||
| DOI: | 10.1016/j.cell.2016.12.012 | |||||||||
| Record Number: | CaltechAUTHORS:20170123-094833526 | |||||||||
| Persistent URL: | https://resolver.caltech.edu/CaltechAUTHORS:20170123-094833526 | |||||||||
| Official Citation: | Qian Zhang, Michael J. Lenardo, David Baltimore, 30 Years of NF-κB: A Blossoming of Relevance to Human Pathobiology, Cell, Volume 168, Issues 1–2, 12 January 2017, Pages 37-57, ISSN 0092-8674, http://dx.doi.org/10.1016/j.cell.2016.12.012. | |||||||||
| Usage Policy: | No commercial reproduction, distribution, display or performance rights in this work are provided. | |||||||||
| ID Code: | 73612 | |||||||||
| Collection: | CaltechAUTHORS | |||||||||
| Deposited By: | Tony Diaz | |||||||||
| Deposited On: | 26 Jan 2017 00:59 | |||||||||
| Last Modified: | 06 Apr 2022 19:27 |
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