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Barium titanate nanoparticles used as second harmonic radiation imaging probes for cell imaging

Hsieh, Chia-Lung and Grange, Rachel and Pu, Ye and Psaltis, Demetri (2009) Barium titanate nanoparticles used as second harmonic radiation imaging probes for cell imaging. In: Advanced Microscopy Techniques. Proceedings of SPIE. No.7367. Society of Photo-Optical Instrumentation Engineers (SPIE) , Bellingham, WA, Art. No. 73670D. ISBN 9780819476432. https://resolver.caltech.edu/CaltechAUTHORS:20170124-102704755

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Abstract

Luminescent markers play a key role in imaging techniques for life science since they provide a contrast mechanism between signal and background. We describe a new type of marker using second harmonic generation (SHG) from noncentrosymmetric BaTiO_3 nanocrystals. These nanoparticles are attractive due to their stable, non-saturating and coherent signal with a femtosecond-scale response time and broad flexibility in the choice of excitation wavelength. In this paper, we report the use of nanoparticles for cell imaging. We first stabilized the BaTiO_3 nanoparticles in suspension and characterized the optical properties. We also demonstrated the functionalization of BaTiO_3 nanoparticles by conjugating IgG antibody on the surface of the nanoparticles. These functionalized nanocrystals are capable of specific labeling the antigens of interest.


Item Type:Book Section
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1117/12.831500DOIArticle
http://proceedings.spiedigitallibrary.org/proceeding.aspx?articleid=780798PublisherArticle
Additional Information:© 2009 Society of Photo-Optical Instrumentation Engineers (SPIE).
Subject Keywords:second harmonic generation, barium titanate, nanoparticles, biological cells, antibody
Series Name:Proceedings of SPIE
Issue or Number:7367
Record Number:CaltechAUTHORS:20170124-102704755
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20170124-102704755
Official Citation:Chia-Lung Hsieh ; Rachel Grange ; Ye Pu ; Demetri Psaltis; Barium titanate nanoparticles used as second harmonic radiation imaging probes for cell imaging. Proc. SPIE 7367, Advanced Microscopy Techniques, 73670D (July 01, 2009); doi:10.1117/12.831500.
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:73662
Collection:CaltechAUTHORS
Deposited By: Ruth Sustaita
Deposited On:26 Jan 2017 20:12
Last Modified:03 Oct 2019 16:30

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