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A Solvent-Free Method for Isotopically or Radioactively Labeling Cyclodextrins and Cyclodextrin-Containing Polymers

Zeidan, Ryan K. and Kalovidouris, Stacey A. and Schluep, Thomas and Fazio, Robert and Andresini, Robert and Davis, Mark E. (2006) A Solvent-Free Method for Isotopically or Radioactively Labeling Cyclodextrins and Cyclodextrin-Containing Polymers. Bioconjugate Chemistry, 17 (6). pp. 1624-1626. ISSN 1043-1802. https://resolver.caltech.edu/CaltechAUTHORS:20170125-093852720

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Abstract

A method for installing a distinguishable label onto cyclodextrins or cyclodextrin-containing polymers is reported. Cyclodextrins (CD) and cyclodextrin-containing polymers are exposed to labeled (^2H or ^(14)C) ethylene oxide (EO) vapor and the alcohol groups on the CD ring open the EO to give ether-linked labeled methylenes and a terminal alcohol. This method provides for the incorporation of an easily tracked and quantified label without the use of solvents or purification steps. The method can be generalized for use with materials that contain nucleophiles other than alcohols, e.g., amines.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1021/bc060211eDOIArticle
http://pubs.acs.org/doi/full/10.1021/bc060211ePublisherArticle
http://pubs.acs.org/doi/suppl/10.1021/bc060211eRelated ItemSupporting Information
Additional Information:© 2006 American Chemical Society. Received 12 July 2006; Published online 31 October 2006; Published in print 1 November 2006.
Issue or Number:6
Record Number:CaltechAUTHORS:20170125-093852720
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20170125-093852720
Official Citation:A Solvent-Free Method for Isotopically or Radioactively Labeling Cyclodextrins and Cyclodextrin-Containing Polymers Ryan K. Zeidan,†, Stacey A. Kalovidouris,§, Thomas Schluep,§, Robert Fazio,#, Robert Andresini,# and, and Mark E. Davis*,† Bioconjugate Chemistry 2006 17 (6), 1624-1626 DOI: 10.1021/bc060211e
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:73709
Collection:CaltechAUTHORS
Deposited By: Ruth Sustaita
Deposited On:25 Jan 2017 19:05
Last Modified:03 Oct 2019 16:30

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