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Photoacoustic tomography of biological tissues with high cross-section resolution: Reconstruction and experiment

Wang, Xueding and Xu, Yuan and Xu, Minghua and Yokoo, Seiichirou and Fry, Edward S. and Wang, Lihong V. (2002) Photoacoustic tomography of biological tissues with high cross-section resolution: Reconstruction and experiment. Medical Physics, 29 (12). pp. 2799-2805. ISSN 0094-2405. http://resolver.caltech.edu/CaltechAUTHORS:20170201-134935888

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Abstract

A modified back-projection approach deduced from an exact reconstruction solution was applied to our photoacoustic tomography of the optical absorption in biological tissues. Pulses from a Ti:sapphire laser (4.7 ns FWHM at 789.2 nm) were employed to generate a distribution of photoacoustic sources in a sample. The sources were detected by a wide-band nonfocused ultrasonic transducer at different positions around the imaging cross section perpendicular to the axis of the laser irradiation. Reconstructed images of phantoms made from chicken breast tissue agreed well with the structures of the samples. The resolution in the imaging cross section was experimentally demonstrated to be better than 60 μm when a 10 MHz transducer (140% bandwidth at −60 dB) was employed, which was nearly diffraction limited by the detectable photoacoustic waves of the highest frequency.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1118/1.1521720DOIArticle
http://onlinelibrary.wiley.com/doi/10.1118/1.1521720/abstractPublisherArticle
ORCID:
AuthorORCID
Xu, Yuan0000-0001-9326-2197
Wang, Lihong V.0000-0001-9783-4383
Additional Information:© 2002 American Association of Physicists in Medicine. Received 26 December 2001; accepted for publication 25 September 2002; published 27 November 2002. This project was sponsored in part by the U.S. Army Medical Research and Material Command Grant No. DAMD 17-00-1-0455, the National Institutes of Health Grant No. R01 CA71980, the National Science Foundation Grant No. BES-9734491, Texas Higher Education Coordinating Board Grant No. ARP 000512-0123-1999, and the Robert A. Welch Foundation Grant No. A-1218.
Funders:
Funding AgencyGrant Number
Army Medical Research and Material CommandDAMD 17-00-1-0455
NIHR01 CA71980
NSFBES-9734491
Texas Higher Education Coordinating BoardARP 000512-0123-1999
Robert A. Welch FoundationA-1218
Subject Keywords:photoacoustic tomography, optoacoustic tomography, laser, reconstruction, imaging
Record Number:CaltechAUTHORS:20170201-134935888
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:20170201-134935888
Official Citation:Wang, X., Xu, Y., Xu, M., Yokoo, S., Fry, E. S. and Wang, L. V. (2002), Photoacoustic tomography of biological tissues with high cross-section resolution: Reconstruction and experiment. Med. Phys., 29: 2799–2805. doi:10.1118/1.1521720
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:73941
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:02 Feb 2017 03:51
Last Modified:02 Feb 2017 03:51

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