Wang, Xueding and Xu, Yuan and Xu, Minghua and Yokoo, Seiichirou and Fry, Edward S. and Wang, Lihong V. (2002) Photoacoustic tomography of biological tissues with high cross-section resolution: Reconstruction and experiment. Medical Physics, 29 (12). pp. 2799-2805. ISSN 0094-2405. doi:10.1118/1.1521720. https://resolver.caltech.edu/CaltechAUTHORS:20170201-134935888
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Abstract
A modified back-projection approach deduced from an exact reconstruction solution was applied to our photoacoustic tomography of the optical absorption in biological tissues. Pulses from a Ti:sapphire laser (4.7 ns FWHM at 789.2 nm) were employed to generate a distribution of photoacoustic sources in a sample. The sources were detected by a wide-band nonfocused ultrasonic transducer at different positions around the imaging cross section perpendicular to the axis of the laser irradiation. Reconstructed images of phantoms made from chicken breast tissue agreed well with the structures of the samples. The resolution in the imaging cross section was experimentally demonstrated to be better than 60 μm when a 10 MHz transducer (140% bandwidth at −60 dB) was employed, which was nearly diffraction limited by the detectable photoacoustic waves of the highest frequency.
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Additional Information: | © 2002 American Association of Physicists in Medicine. Received 26 December 2001; accepted for publication 25 September 2002; published 27 November 2002. This project was sponsored in part by the U.S. Army Medical Research and Material Command Grant No. DAMD 17-00-1-0455, the National Institutes of Health Grant No. R01 CA71980, the National Science Foundation Grant No. BES-9734491, Texas Higher Education Coordinating Board Grant No. ARP 000512-0123-1999, and the Robert A. Welch Foundation Grant No. A-1218. | ||||||||||||
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Subject Keywords: | photoacoustic tomography, optoacoustic tomography, laser, reconstruction, imaging | ||||||||||||
Issue or Number: | 12 | ||||||||||||
DOI: | 10.1118/1.1521720 | ||||||||||||
Record Number: | CaltechAUTHORS:20170201-134935888 | ||||||||||||
Persistent URL: | https://resolver.caltech.edu/CaltechAUTHORS:20170201-134935888 | ||||||||||||
Official Citation: | Wang, X., Xu, Y., Xu, M., Yokoo, S., Fry, E. S. and Wang, L. V. (2002), Photoacoustic tomography of biological tissues with high cross-section resolution: Reconstruction and experiment. Med. Phys., 29: 2799–2805. doi:10.1118/1.1521720 | ||||||||||||
Usage Policy: | No commercial reproduction, distribution, display or performance rights in this work are provided. | ||||||||||||
ID Code: | 73941 | ||||||||||||
Collection: | CaltechAUTHORS | ||||||||||||
Deposited By: | Tony Diaz | ||||||||||||
Deposited On: | 02 Feb 2017 03:51 | ||||||||||||
Last Modified: | 11 Nov 2021 05:23 |
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