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Biochemistry and neuroscience: the twain need to meet

Kennedy, Mary B. (2017) Biochemistry and neuroscience: the twain need to meet. Current Opinion in Neurobiology, 43 . pp. 79-86. ISSN 0959-4388. PMCID PMC5447485. doi:10.1016/j.conb.2017.01.004.

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Neuroscience has come to mean the study of electrophysiology of neurons and synapses, micro and macro-scale neuroanatomy, and the functional organization of brain areas. The molecular axis of the field, as reflected in textbooks, often includes only descriptions of the structure and function of individual channels and receptor proteins, and the extracellular signals that guide development and repair. Studies of cytosolic ‘molecular machines’, large assemblies of proteins that orchestrate regulation of neuronal functions, have been neglected. However, a complete understanding of brain function that will enable new strategies for treatment of the most intractable neural disorders will require that in vitro biochemical studies of molecular machines be reintegrated into the field of neuroscience.

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Kennedy, Mary B.0000-0003-1369-0525
Additional Information:© 2017 Elsevier Ltd. Available online 1 February 2017. The author’s work has been funded by the Allen and Lenabelle Davis Foundation, the Hicks Foundation for Alzheimer’s Research, and by grants from the Gordon and Betty Moore Foundation (Center for Integrative Study of Cell Regulation), the National Institutes of Health, the National Science Foundation, and the Beckman Institute. Conflict of interest statement: Nothing declared.
Funding AgencyGrant Number
Allen and Lenabelle Davis FoundationUNSPECIFIED
Hicks Foundation for Alzheimer’s ResearchUNSPECIFIED
Caltech Beckman InstituteUNSPECIFIED
PubMed Central ID:PMC5447485
Record Number:CaltechAUTHORS:20170202-102002485
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Official Citation:Mary B Kennedy, Biochemistry and neuroscience: the twain need to meet, Current Opinion in Neurobiology, Volume 43, April 2017, Pages 79-86, ISSN 0959-4388, (//
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:73983
Deposited By: Tony Diaz
Deposited On:02 Feb 2017 19:13
Last Modified:11 Nov 2021 05:23

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