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Ultrasound-modulated optical tomography of biological tissue by use of contrast of laser speckles

Li, Jun and Ku, Geng and Wang, Lihong V. (2002) Ultrasound-modulated optical tomography of biological tissue by use of contrast of laser speckles. Applied Optics, 41 (28). pp. 6030-6035. ISSN 0003-6935. doi:10.1364/AO.41.006030. https://resolver.caltech.edu/CaltechAUTHORS:20170203-092623874

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Abstract

Ultrasound-modulated optical tomography based on the measurement of laser-speckle contrast was investigated. An ultrasonic beam was focused into a biological-tissue sample to modulate the laser light passing through the ultrasonic column inside the tissue. The contrast of the speckle pattern formed by the transmitted light was found to depend on the ultrasonic modulation and could be used for imaging. Variation in the speckle contrast reflected optical inhomogeneity in the tissue. With this technique, two-dimensional images of biological-tissue samples of as much as 25 mm thick were successfully obtained with a low-power laser. The technique was experimentally compared with speckle-contrast-based, purely optical imaging and with parallel-detection imaging techniques, and the advantages over each were demonstrated.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1364/AO.41.006030DOIArticle
https://www.osapublishing.org/ao/abstract.cfm?uri=ao-41-28-6030PublisherArticle
ORCID:
AuthorORCID
Wang, Lihong V.0000-0001-9783-4383
Additional Information:© 2002 Optical Society of America. Received 14 December 2001; revised manuscript received 18 April 2002. This project was sponsored in part by the National Institutes of Health grant R01 CA71980; the National Science Foundation grant BES-9734491; and the Texas Higher Education Coordinating Board grant 000512-0123-1999.
Funders:
Funding AgencyGrant Number
NIHR01 CA71980
NSFBES-9734491
Texas Higher Education Coordinating Board000512-0123-1999
Issue or Number:28
Classification Code:OCIS codes: 170.3880, 120.6150, 110.7050, 110.7170
DOI:10.1364/AO.41.006030
Record Number:CaltechAUTHORS:20170203-092623874
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20170203-092623874
Official Citation:Jun Li, Geng Ku, and Lihong V. Wang, "Ultrasound-modulated optical tomography of biological tissue by use of contrast of laser speckles," Appl. Opt. 41, 6030-6035 (2002)
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:74009
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:03 Feb 2017 17:35
Last Modified:11 Nov 2021 05:24

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