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Cross-Reactive Chemical Sensor Arrays

Albert, Keith J. and Lewis, Nathan S. and Schauer, Caroline L. and Sotzing, Gregory A. and Stitzel, Shannon E. and Vaid, Thomas P. and Walt, David R. (2000) Cross-Reactive Chemical Sensor Arrays. Chemical Reviews, 100 (7). pp. 2595-2626. ISSN 0009-2665. doi:10.1021/cr980102w.

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Conventional approaches to chemical sensors have traditionally made use of a “lock-and-key” design, wherein a specific receptor is synthesized in order to strongly and highly selectively bind the analyte of interest.1-6 A related approach involves exploiting a general physicochemical effect selectively toward a single analyte, such as the use of the ionic effect in the construction of a pH electrode. In the first approach, selectivity is achieved through recognition of the analyte at the receptor site, and in the second, selectivity is achieved through the transduction process in which the method of detection dictates which species are sensed. Such approaches are appropriate when a specific target compound is to be identified in the presence of controlled backgrounds and interferences. However, this type of approach requires the synthesis of a separate, highly selective sensor for each analyte to be detected. In addition, this type of approach is not particularly useful for analyzing, classifying, or assigning human value judgments to the composition of complex vapor mixtures such as perfumes, beers, foods, mixtures of solvents, etc.

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Lewis, Nathan S.0000-0001-5245-0538
Additional Information:© 2000 American Chemical Society. Received 17 August 1999. Published online 24 June 2000. Published in print 1 July 2000. We acknowledge the Army Research Office, NASA, and DARPA for support of sensor array work at Caltech and acknowledge DARPA, the Office of Naval Research, the National Institutes of Health, and the Department of Energy for support at Tufts that made preparation of this review, along with some of the examples discussed herein, possible.
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Army Research Office (ARO)UNSPECIFIED
Defense Advanced Research Projects Agency (DARPA)UNSPECIFIED
Office of Naval Research (ONR)UNSPECIFIED
Department of Energy (DOE)UNSPECIFIED
Issue or Number:7
Record Number:CaltechAUTHORS:20170203-135415951
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Official Citation:Cross-Reactive Chemical Sensor Arrays Keith J. Albert, Nathan S. Lewis, Caroline L. Schauer, Gregory A. Sotzing, Shannon E. Stitzel, Thomas P. Vaid, and David R. Walt Chemical Reviews 2000 100 (7), 2595-2626 DOI: 10.1021/cr980102w
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:74036
Deposited By: Ruth Sustaita
Deposited On:04 Feb 2017 02:46
Last Modified:11 Nov 2021 05:24

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