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Cross-Reactive Chemical Sensor Arrays

Albert, Keith J. and Lewis, Nathan S. and Schauer, Caroline L. and Sotzing, Gregory A. and Stitzel, Shannon E. and Vaid, Thomas P. and Walt, David R. (2000) Cross-Reactive Chemical Sensor Arrays. Chemical Reviews, 100 (7). pp. 2595-2626. ISSN 0009-2665. https://resolver.caltech.edu/CaltechAUTHORS:20170203-135415951

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Abstract

Conventional approaches to chemical sensors have traditionally made use of a “lock-and-key” design, wherein a specific receptor is synthesized in order to strongly and highly selectively bind the analyte of interest.1-6 A related approach involves exploiting a general physicochemical effect selectively toward a single analyte, such as the use of the ionic effect in the construction of a pH electrode. In the first approach, selectivity is achieved through recognition of the analyte at the receptor site, and in the second, selectivity is achieved through the transduction process in which the method of detection dictates which species are sensed. Such approaches are appropriate when a specific target compound is to be identified in the presence of controlled backgrounds and interferences. However, this type of approach requires the synthesis of a separate, highly selective sensor for each analyte to be detected. In addition, this type of approach is not particularly useful for analyzing, classifying, or assigning human value judgments to the composition of complex vapor mixtures such as perfumes, beers, foods, mixtures of solvents, etc.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1021/cr980102wDOIArticle
http://pubs.acs.org/doi/abs/10.1021/cr980102wPublisherArticle
ORCID:
AuthorORCID
Lewis, Nathan S.0000-0001-5245-0538
Additional Information:© 2000 American Chemical Society. Received 17 August 1999. Published online 24 June 2000. Published in print 1 July 2000. We acknowledge the Army Research Office, NASA, and DARPA for support of sensor array work at Caltech and acknowledge DARPA, the Office of Naval Research, the National Institutes of Health, and the Department of Energy for support at Tufts that made preparation of this review, along with some of the examples discussed herein, possible.
Funders:
Funding AgencyGrant Number
Army Research Office (ARO)UNSPECIFIED
NASAUNSPECIFIED
Defense Advanced Research Projects Agency (DARPA)UNSPECIFIED
Office of Naval Research (ONR)UNSPECIFIED
NIHUNSPECIFIED
Department of Energy (DOE)UNSPECIFIED
Issue or Number:7
Record Number:CaltechAUTHORS:20170203-135415951
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20170203-135415951
Official Citation:Cross-Reactive Chemical Sensor Arrays Keith J. Albert, Nathan S. Lewis, Caroline L. Schauer, Gregory A. Sotzing, Shannon E. Stitzel, Thomas P. Vaid, and David R. Walt Chemical Reviews 2000 100 (7), 2595-2626 DOI: 10.1021/cr980102w
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:74036
Collection:CaltechAUTHORS
Deposited By: Ruth Sustaita
Deposited On:04 Feb 2017 02:46
Last Modified:03 Oct 2019 16:34

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