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Scanning thermoacoustic tomography in biological tissue

Ku, Geng and Wang, Lihong V. (2000) Scanning thermoacoustic tomography in biological tissue. Medical Physics, 27 (5). pp. 1195-1202. ISSN 0094-2405. http://resolver.caltech.edu/CaltechAUTHORS:20170203-152231282

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Abstract

Microwave-induced thermoacoustic tomography was explored to image biological tissue. Short microwave pulses irradiated tissue to generate acoustic waves by thermoelastic expansion. The microwave-induced thermoacoustic waves were detected with a focused ultrasonic transducer. Each time-domain signal from the ultrasonic transducer represented a one-dimensional image along the acoustic axis of the ultrasonic transducer similar to an ultrasonic A-scan. Scanning the system perpendicularly to the acoustic axis of the ultrasonic transducer would generate multi-dimensional images. Two-dimensional tomographic images of biological tissue were obtained with 3-GHz microwaves. The axial and lateral resolutions were characterized. The time-domain piezo-electric signal from the ultrasonic transducer in response to the thermoacoustic signal was simulated theoretically, and the theoretical result agreed with the experimental result very well.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1118/1.598984DOIArticle
http://onlinelibrary.wiley.com/doi/10.1118/1.598984/abstractPublisherArticle
ORCID:
AuthorORCID
Wang, Lihong V.0000-0001-9783-4383
Additional Information:© 2000 American Association of Physicists in Medicine. Received 5 August 1999; accepted for publication 2 March 2000. Thanks to X. Zhao and G. Yao for their assistance in electronics and computer programming, respectively. This project was sponsored in part by the National Institutes of Health Grants Nos. R29 CA68562, R01 CA71980, and R21 CA83760 and by the National Science Foundation Grant no. BES-9734491.
Funders:
Funding AgencyGrant Number
NIHR29 CA68562
NIHR01 CA71980
NIHR21 CA83760
NSFBES-9734491
Subject Keywords:microwave; ultrasonics; thermoacoustics; photoacoustics; tomography
Record Number:CaltechAUTHORS:20170203-152231282
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:20170203-152231282
Official Citation:Ku, G. and Wang, L. V. (2000), Scanning thermoacoustic tomography in biological tissue. Med. Phys., 27: 1195–1202. doi:10.1118/1.598984
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:74046
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:04 Feb 2017 02:38
Last Modified:04 Feb 2017 02:38

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