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Theoretical and experimental studies of ultrasound-modulated optical tomography in biological tissue

Yao, Gang and Wang, Lihong V. (2000) Theoretical and experimental studies of ultrasound-modulated optical tomography in biological tissue. Applied Optics, 39 (4). pp. 659-664. ISSN 0003-6935. doi:10.1364/AO.39.000659.

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Ultrasound-modulated optical tomography in biological tissue was studied both theoretically and experimentally. An ultrasonic beam was focused into biological tissue samples to modulate the laser light passing through the ultrasonic beam inside the tissue. The ultrasound-modulated laser light reflects the local optical and mechanical properties in the ultrasonic beam and permits tomographic imaging of biological tissues by scanning. Parallel detection of the speckle field formed by the transmitted laser light was implemented with the source-synchronous-illumination lock-in technique to improve the signal-to-noise ratio. Two-dimensional images of biological tissues were successfully obtained experimentally with a laser beam at either normal or oblique incidence, which showed that ultrasound-modulated optical tomography depends on diffuse light rather than on ballistic light. Monte Carlo simulations showed that the modulation depth decreased much more slowly than the diffuse transmittance, which indicated the possibility that even thicker biological tissues can be imaged with this technique.

Item Type:Article
Related URLs:
URLURL TypeDescription
Wang, Lihong V.0000-0001-9783-4383
Additional Information:© 2000 Optical Society of America. Received 21 July 1999; revised manuscript received 29 September 1999. This project was sponsored in part by National Institutes of Health grants R29 CA68562, R01 CA71980, and R21 CA83760 and by National Science Foundation grant BES-9734491.
Funding AgencyGrant Number
NIHR29 CA68562
NIHR01 CA71980
NIHR21 CA83760
Issue or Number:4
Classification Code:OCIS codes: 170.3880, 120.6150, 110.7050, 110.7170
Record Number:CaltechAUTHORS:20170203-152520639
Persistent URL:
Official Citation:Gang Yao and Lihong V. Wang, "Theoretical and experimental studies of ultrasound-modulated optical tomography in biological tissue," Appl. Opt. 39, 659-664 (2000)
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:74047
Deposited By: Tony Diaz
Deposited On:03 Feb 2017 23:49
Last Modified:11 Nov 2021 05:24

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