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Cys-Loop Neuroreceptors: Structure to the Rescue?

Dougherty, Dennis A. (2008) Cys-Loop Neuroreceptors: Structure to the Rescue? Chemical Reviews, 108 (5). pp. 1642-1653. ISSN 0009-2665. doi:10.1021/cr078207z.

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Dennis A. Dougherty is the George Grant Hoag Professor of Chemistry at the California Institute of Technology. He received his B.S. and M.S. degrees from Bucknell University, and in 1978 he completed his Ph.D. with Kurt Mislow at Princeton University. After a year of postdoctoral studies with Jerome Berson at Yale University, he joined the faculty at Caltech. Professor Dougherty’s research employs the techniques of physical organic chemistry to probe biologically important systems, specifically in the field of neuroscience. He is known for the development of the cation−π interaction, a general noncovalent binding force of pervasive importance in biological systems. More recently, he has pursued chemical-scale studies of neuroreceptors and ion channels, such as the nicotinic acetylcholine receptor. Professor Dougherty’s research has been recognized with a number of awards, including the ACS James Flack Norris Award for Physical Organic Chemistry, the AstraZeneca Excellence in Chemistry Award, the Arthur C. Cope Scholar Award, and the Javits Neuroscience Investigator, NIH. He is a Fellow of the American Association for the Advancement of Science and a Fellow of the American Academy of Arts and Science. He is also the coauthor with Dr. Eric Anslyn of the influential textbook Modern Physical Organic Chemistry.

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Dougherty, Dennis A.0000-0003-1464-2461
Additional Information:© 2008 American Chemical Society. Received 7 September 2007. Published online 1 May 2008. Published in print 1 May 2008. I thank the extraordinarily talented graduate students and postdocs whose intelligence, hard work, and creativity produced the results described here. Much of this work results from ongoing and enjoyable collaborations with Henry Lester and Sarah Lummis, to whom I am grateful. Our work has been supported by the National Institutes of Health (NS-34407) and, more recently, the California Tobacco-Related Disease Research Program of the University of California, Grant Number 16RT-0160. Note Added During Proof: Recently, a full crystal structure at 3.3 Å resolution of a bacterial channel termed ELIC has been reported. The channel is pentameric and clearly related to the Cys-loop receptors, although there is no Cys-loop and, at present, the natural ligand is not known. Hilf, R. J. C.; Dutzler, R. Nature, 2008, 452, 375–379.
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California Tobacco-Related Disease Research Program16RT-0160
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Official Citation:Cys-Loop Neuroreceptors: Structure to the Rescue? Dennis A. Dougherty Chemical Reviews 2008 108 (5), 1642-1653 DOI: 10.1021/cr078207z
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:74051
Deposited By: Ruth Sustaita
Deposited On:06 Feb 2017 16:08
Last Modified:11 Nov 2021 05:24

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