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Antibody gene transfer with adeno-associated viral vectors as a method for HIV prevention

Brady, Jacqueline M. and Baltimore, David and Balazs, Alejandro B. (2017) Antibody gene transfer with adeno-associated viral vectors as a method for HIV prevention. Immunological Reviews, 275 (1). pp. 324-333. ISSN 0105-2896. https://resolver.caltech.edu/CaltechAUTHORS:20170206-091735457

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Abstract

Broadly neutralizing antibodies (bNAbs) against human immunodeficiency virus (HIV) show great promise in HIV prevention as they are capable of potently neutralizing a considerable breadth of genetically diverse strains. Passive transfer of monoclonal bNAb proteins can confer protection in animal models of HIV infection at modest concentrations, inspiring efforts to develop an HIV vaccine capable of eliciting bNAb responses. However, these antibodies demonstrate high degrees of somatic mutation and other unique characteristics that may hinder the ability of conventional approaches to consistently and effectively produce bNAb analogs. As an alternative strategy, we and others have proposed vector-mediated gene transfer to generate long-term, systemic production of bNAbs in the absence of immunization. Herein, we review the use of adeno-associated virus (AAV) vectors for delivery of HIV bNAbs and antibody-like proteins and summarize both the advantages and disadvantages of this strategy as a method for HIV prevention.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1111/imr.12478DOIArticle
http://onlinelibrary.wiley.com/wol1/doi/10.1111/imr.12478/abstractPublisherArticle
ORCID:
AuthorORCID
Baltimore, David0000-0001-8723-8190
Additional Information:© 2017 John Wiley & Sons A/S. Issue online: 30 JAN 2017. Version of Record online: 30 JAN 2017. A. B. B. is supported by the National Institutes for Drug Abuse (NIDA) Avenir New Innovator Award DP2DA040254, the MGH Transformative Scholars Program as well as funding from the Charles H. Hood Foundation. This independent research was supported by the Gilead Sciences Research Scholars Program in HIV. D. B. and A. B. B. were supported by the National Institutes of Health (HHSN266200500035C) through a contract from the NIAID. There are no conflicts of interest.
Funders:
Funding AgencyGrant Number
NIHDP2DA040254
MGH Transformative Scholars ProgramUNSPECIFIED
Charles H. Hood FoundationUNSPECIFIED
Gilead Sciences Research Scholars Program in HIVUNSPECIFIED
NIHHHSN266200500035C
Subject Keywords:adeno-associated virus;antibody gene transfer;broadly neutralizing antibodies; HIV ;immunoprophylaxis
Issue or Number:1
Record Number:CaltechAUTHORS:20170206-091735457
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20170206-091735457
Official Citation:Brady, J. M., Baltimore, D. and Balazs, A. B. (2017), Antibody gene transfer with adeno-associated viral vectors as a method for HIV prevention. Immunological Reviews, 275: 324–333. doi: 10.1111/imr.12478
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:74069
Collection:CaltechAUTHORS
Deposited By: Ruth Sustaita
Deposited On:06 Feb 2017 17:29
Last Modified:03 Oct 2019 16:34

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