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Regulatory factors for initial T lymphocyte lineage specification

Rothenberg, Ellen V. (2007) Regulatory factors for initial T lymphocyte lineage specification. Current Opinion in Hematology, 14 (4). pp. 322-329. ISSN 1065-6251. doi:10.1097/MOH.0b013e3281de72a8.

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Purpose of review: Initiation of T lymphocyte development depends on balanced regulatory inputs from multiple essential transcription factors. This review highlights contributions of E2A, hematopoietic transcription factor PU.1, growth factor independence (Gfi)-1, T cell factor (TCF)-1, and Runx factors and their interactions with the Notch pathway to promote T cell development. Recent findings: E2A and Runx family factors have been implicated in establishing competent precursors in which Notch signaling can induce the T cell program. An early role was also indicated for PU.1. Later PU.1 activities are antagonistic to pro-T cell factors, however, including E proteins, Myb, Gfi-1, and TCF-1. Diversion to a non-T lineage can be promoted by PU.1, CCAAT/enhancer binding protein, or even GATA and TCF, but these diversion mechanisms are blocked by Notch signaling. An emergent gene network summarizes the cross-regulatory relationships among these factors. Summary: Entry into the T-cell pathway is controlled by a dynamic balance among essential regulatory factors that depend on Notch signaling not only to trigger initiation of the T-cell program but also to maintain the lineage fidelity of their collective action.

Item Type:Article
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Rothenberg, Ellen V.0000-0002-3901-347X
Additional Information:© 2007 Lippincott Williams & Wilkins, Inc.
Subject Keywords:gene networks; lineage commitment; Notch; T-cell development; transcription factors
Issue or Number:4
Record Number:CaltechAUTHORS:20170206-111340463
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:74077
Deposited By: Tony Diaz
Deposited On:06 Feb 2017 20:24
Last Modified:11 Nov 2021 05:24

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